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Odf1  -  outer dense fiber of sperm tails 1

Rattus norvegicus

Synonyms: Odf27, Odfp, Outer dense fiber protein 1, Protein RT7, RTS 5/1, ...
 
 
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High impact information on Odf1

  • Here we characterize a testis-specific nuclear factor, TTF-D, which is able to complex with both binding sites and stimulates Odf1 promoter activity [1].
  • Transcription starts in step 6 spermatids, which coincides with transcription of the major outer dense fiber protein gene odf1 (Burmester, S., and Hoyer-Fender, S. (1996) Mol. Reprod. Dev. 45, 10-20) and with the formation of the sperm tail [2].
  • Spag4, a novel sperm protein, binds outer dense-fiber protein Odf1 and localizes to microtubules of manchette and axoneme [3].
  • We identified two putative leucine zippers in the C-terminal part of the Spag5 protein, the downstream one of which is involved in interaction with Odf1 [4].
  • Transcription and translation of the outer dense fiber gene (Odf1) during spermiogenesis in the rat. A study by in situ analyses and polysome fractionation [5].
 

Biological context of Odf1

  • It seems therefore, that translation of Odf1 is greatly enhanced in the maturation phase of spermiogenesis during which a marked increase in diameter of outer dense fibers takes place [5].
 

Anatomical context of Odf1

  • In contrast to Odf1 and Odf2, Spag4 protein localizes to two microtubule-containing spermatid structures [3].
  • Molecular cloning and developmental expression of an mRNA encoding the 27 kDa outer dense fiber protein of rat spermatozoa [6].
  • In adult rat testis about 30% of Odf1 mRNA is associated with the polysomal fraction, but the bulk is stored in translationally inactive ribonucleoprotein particles [5].
  • Transcription and translation of the Odf1 gene encoding the major protein of sperm tail outer dense fibers has been investigated in rat spermatogenesis [5].
 

Associations of Odf1 with chemical compounds

  • The distribution of Odf1 mRNA and the respective transcript sizes in polysomes and translationally inactive nonpolysomal ribonucleoprotein particles has been investigated by fractionation on sucrose gradients and Northern blot analysis of the isolated RNA [5].
 

Analytical, diagnostic and therapeutic context of Odf1

  • Northern blot analysis of fractionated RNA digested with RHaseH revealed the presence of both Odf1 transcripts (Burfeind and Hoyer-Fender, 1991: Dev Biol 148: 195-204; Burfeind et al., 1993: Eur J Biochem 216: 497-505) on polysomes [5].
  • Odf1 mRNA was detected by in situ hybridization from step 6 round spermatids up to step 17 [5].

References

 
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