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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Asrgl1  -  asparaginase like 1

Rattus norvegicus

Synonyms: Alp, Asparaginase-like protein 1, Asparaginase-like sperm autoantigen, Beta-aspartyl-peptidase, Glial asparaginase, ...
 
 
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High impact information on Asrgl1

  • In brain Gliap is exclusively expressed in astrocytes and prominently present in structures reminiscent of glial endfeet [1].
  • Moreover, in contrast to glycosylasparaginases Gliap is enriched in the cytosolic fraction and not in lysosomes [1].
  • These data suggest that Gliap is involved in astroglial production of the neuroactive amino acid L-aspartate [1].
  • Structural modelling suggests that Gliap is an atypical mammalian type-I asparaginase inasmuch as it harbours the active centre of a type-I glycosylasparaginase but, like plant-type asparaginases, lacks their auto-proteolytic site and, in addition, exhibits significant type-II L-asparaginase enzymatic activity [1].

References

  1. Gliap--a novel untypical L-asparaginase localized to rat brain astrocytes. Dieterich, D.C., Landwehr, M., Reissner, C., Smalla, K.H., Richter, K., Wolf, G., Böckers, T.M., Gundelfinger, E.D., Kreutz, M.R. J. Neurochem. (2003) [Pubmed]
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