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Gene Review

Pdp2  -  pyruvate dehyrogenase phosphatase...

Rattus norvegicus

Synonyms: PDP 2, PDPC 2, Pyruvate dehydrogenase phosphatase catalytic subunit 2
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High impact information on Pdp2

  • Starvation and streptozotocin-induced diabetes cause decreases in PDP2 mRNA abundance, PDP2 protein amount, and PDP activity in rat heart and kidney [1].
  • Both PDP-2 (enkephalinase) and PDP-3 are apparently present in nerve terminal membranes predominantly as inactive proenzyme precursors, which elute from DEAE-cellulose at high salt concentration, and are activated very slowly by a process involving one or more trypsin-like enzymes [2].

Associations of Pdp2 with chemical compounds

  • Enkephalinase (PDP-2) cleaves 80 nM [3H-Tyr1, Leu5]-enkephalin, but not Hip-His-Leu; it is not inhibited by any of the standard competitive inhibitors of angiotensin-converting enzyme (all analogs of carboxyl-terminal peptide sequences Phe-Ala-Pro or Ala-Pro), but is strongly inhibited by captopril analogs such as thiorphan (Phe-Gly analog) [2].


  1. Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney. Huang, B., Wu, P., Popov, K.M., Harris, R.A. Diabetes (2003) [Pubmed]
  2. Purification and characterization of enkephalinase, angiotensin converting enzyme, and a third peptidyldipeptidase from rat brain. Cushman, D.W., Gordon, E.M., Wang, F.L., Cheung, H.S., Tung, R., Delaney, N.G. Life Sci. (1983) [Pubmed]
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