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Gene Review

RT1-D  -  RT1 region, class II

Rattus norvegicus

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Disease relevance of RT1-D

 

High impact information on RT1-D

  • Thus, while the BMAC-4 antibody is likely to have had a variety of different effects on RT1-D positive recipient cells, the locus specificity of the immunosuppression is consistent with an important component of those effects being the blocking of presentation of WAG donor alloantigens by PVG RT1-D class II antigens on PVG antigen-presenting cells [2].
  • The rat major histocompatibility complex loci RT1-B and RT1-D are equivalent to the human leucocyte antigens HLA-DQ and HLA-DR respectively [3].
  • Ursodeoxycholic acid alone or in combination with cholic acid increased the expression of RT1A compared to normal controls, of RT1B compared to AOM-treated rats, and of RT1D compared to controls or AOM-treated rats [4].
  • Furthermore, the diabetic rats heterozygous by serotyping at the RT1A class I loci were also heterozygous at the RT1B and RT1D loci of the class II region and did not show evidence of a recombinant haplotype when examined by Southern blot analyses using molecular probes for class I and class II genes [5].
  • The major histocompatibility complex (MHC) class II (Ia) antigens (RT1B and RT1D in rat), detected with OX6 antibody, and OX17 antibody, may be present on activated rat T-cells [6].
 

Other interactions of RT1-D

  • The rats were classified into 5 groups according to the differences in subregions of the RT1 (rat MHC) between the recipient and the donor: group 1, RT1-A,B,D barrier (the differences of RT1-A,B,D subregions); group 2, RT1-A barrier; group 3, RT1-B,D barrier; group 4, RT1-B barrier; and group 5, RT1-D barrier [7].
 

Analytical, diagnostic and therapeutic context of RT1-D

  • Evidence for processing of WAG antigens by the RT1-D class II MHC molecules of PVG rats during kidney allograft rejection [8].

References

  1. Spontaneous lymphocytic infiltrates of oral mucosa in HgCl2 induced autoimmunity of BN rats: phenotypic characteristics and contact hypersensitivity to Hg. Warfvinge, G., Larsson, A. Regional immunology. (1990) [Pubmed]
  2. Suppression of kidney allograft rejection across full MHC barriers by recipient-specific antibodies to class II MHC antigens. Priestley, C.A., Spencer, S.C., Sawyer, G.J., Fabre, J.W. Transplantation (1992) [Pubmed]
  3. Complementary DNA sequences encoding the rat MHC class II RT1-Bu and RT1-Du alpha and beta chains. Easterfield, A.J., Bradley, J.A., Bolton, E.M. Immunogenetics (2003) [Pubmed]
  4. The effect of bile acids and piroxicam on MHC antigen expression in rat colonocytes during colon cancer development. Rigas, B., Tsioulias, G.J., Allan, C., Wali, R.K., Brasitus, T.A. Immunology (1994) [Pubmed]
  5. A single dose of the MHC-linked susceptibility determinant associated with the RT1u haplotype is permissive for insulin-dependent diabetes mellitus in the BB rat. Fuks, A., Ono, S.J., Colle, E., Guttmann, R.D. Exp. Clin. Immunogenet. (1990) [Pubmed]
  6. Cyclosporine and dexamethasone inhibit T-lymphocyte MHC class II antigens and IL-2 receptor expression in experimental autoimmune uveitis. Chan, C.C., Caspi, R., Mochizuki, M., Diamantstein, T., Gery, I., Nussenblatt, R.B. Immunol. Invest. (1987) [Pubmed]
  7. Effects of major histocompatibility complex matching on graft survival in allogeneic rat limb transplantation. Iwasaki, N., Gohda, T., Itoga, H., Minami, A., Kaneda, K. The Journal of hand surgery. (2001) [Pubmed]
  8. Evidence for processing of WAG antigens by the RT1-D class II MHC molecules of PVG rats during kidney allograft rejection. Priestley, C.A., Spencer, S.S., Sawyer, G.J., Fabre, J.W. Transplant. Proc. (1990) [Pubmed]
 
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