The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

RT1-D  -  RT1 region, class II

Rattus norvegicus

This record was discontinued.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of RT1-D


High impact information on RT1-D

  • Thus, while the BMAC-4 antibody is likely to have had a variety of different effects on RT1-D positive recipient cells, the locus specificity of the immunosuppression is consistent with an important component of those effects being the blocking of presentation of WAG donor alloantigens by PVG RT1-D class II antigens on PVG antigen-presenting cells [2].
  • The rat major histocompatibility complex loci RT1-B and RT1-D are equivalent to the human leucocyte antigens HLA-DQ and HLA-DR respectively [3].
  • Ursodeoxycholic acid alone or in combination with cholic acid increased the expression of RT1A compared to normal controls, of RT1B compared to AOM-treated rats, and of RT1D compared to controls or AOM-treated rats [4].
  • Furthermore, the diabetic rats heterozygous by serotyping at the RT1A class I loci were also heterozygous at the RT1B and RT1D loci of the class II region and did not show evidence of a recombinant haplotype when examined by Southern blot analyses using molecular probes for class I and class II genes [5].
  • The major histocompatibility complex (MHC) class II (Ia) antigens (RT1B and RT1D in rat), detected with OX6 antibody, and OX17 antibody, may be present on activated rat T-cells [6].

Other interactions of RT1-D

  • The rats were classified into 5 groups according to the differences in subregions of the RT1 (rat MHC) between the recipient and the donor: group 1, RT1-A,B,D barrier (the differences of RT1-A,B,D subregions); group 2, RT1-A barrier; group 3, RT1-B,D barrier; group 4, RT1-B barrier; and group 5, RT1-D barrier [7].

Analytical, diagnostic and therapeutic context of RT1-D

  • Evidence for processing of WAG antigens by the RT1-D class II MHC molecules of PVG rats during kidney allograft rejection [8].


  1. Spontaneous lymphocytic infiltrates of oral mucosa in HgCl2 induced autoimmunity of BN rats: phenotypic characteristics and contact hypersensitivity to Hg. Warfvinge, G., Larsson, A. Regional immunology. (1990) [Pubmed]
  2. Suppression of kidney allograft rejection across full MHC barriers by recipient-specific antibodies to class II MHC antigens. Priestley, C.A., Spencer, S.C., Sawyer, G.J., Fabre, J.W. Transplantation (1992) [Pubmed]
  3. Complementary DNA sequences encoding the rat MHC class II RT1-Bu and RT1-Du alpha and beta chains. Easterfield, A.J., Bradley, J.A., Bolton, E.M. Immunogenetics (2003) [Pubmed]
  4. The effect of bile acids and piroxicam on MHC antigen expression in rat colonocytes during colon cancer development. Rigas, B., Tsioulias, G.J., Allan, C., Wali, R.K., Brasitus, T.A. Immunology (1994) [Pubmed]
  5. A single dose of the MHC-linked susceptibility determinant associated with the RT1u haplotype is permissive for insulin-dependent diabetes mellitus in the BB rat. Fuks, A., Ono, S.J., Colle, E., Guttmann, R.D. Exp. Clin. Immunogenet. (1990) [Pubmed]
  6. Cyclosporine and dexamethasone inhibit T-lymphocyte MHC class II antigens and IL-2 receptor expression in experimental autoimmune uveitis. Chan, C.C., Caspi, R., Mochizuki, M., Diamantstein, T., Gery, I., Nussenblatt, R.B. Immunol. Invest. (1987) [Pubmed]
  7. Effects of major histocompatibility complex matching on graft survival in allogeneic rat limb transplantation. Iwasaki, N., Gohda, T., Itoga, H., Minami, A., Kaneda, K. The Journal of hand surgery. (2001) [Pubmed]
  8. Evidence for processing of WAG antigens by the RT1-D class II MHC molecules of PVG rats during kidney allograft rejection. Priestley, C.A., Spencer, S.S., Sawyer, G.J., Fabre, J.W. Transplant. Proc. (1990) [Pubmed]
WikiGenes - Universities