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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Scnn1b  -  sodium channel, non-voltage-gated 1, beta...

Rattus norvegicus

Synonyms: Amiloride-sensitive sodium channel subunit beta, Beta-ENaC, Beta-NaCH, Epithelial Na(+) channel subunit beta, Nonvoltage-gated sodium channel 1 subunit beta, ...
 
 
 
 
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Disease relevance of Scnn1b

 

High impact information on Scnn1b

  • Blood pressure correlated significantly with Scnn1b gene in the recombinant inbred strains [1].
  • RESULTS: The Scnn1b gene was closely linked to the Sa gene on rat chromosome 1 [1].
  • Analysis of near full-length Scnn1b cDNAs from SHR and Dahl rats failed to reveal any coding sequence mutations that could affect the predicted amino acid sequence of the Scnn1b protein [1].
  • If disordered activity of the epithelial cell sodium channel contributes to the pathogenesis of hypertension in the SHR or Dahl models, it must stem from genetic lesions in sequences that regulate Scnn1b function or in sequences important to the structure or function of the other sodium channel subunits [1].

References

  1. Mapping and sequence analysis of the gene encoding the beta subunit of the epithelial sodium channel in experimental models of hypertension. Huang, H., Pravenec, M., Wang, J.M., Kren, V., St Lezin, E., Szpirer, C., Szpirer, J., Kurtz, T.W. J. Hypertens. (1995) [Pubmed]
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