The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Semg1  -  semenogelin I

Rattus norvegicus

Synonyms: RATSVPIIA, SVPIIA, SVS II, SVS2P, Seminal vesicle secretory protein 2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Svs2


Biological context of Svs2

  • Concomitant with the gene analysis, the rat SVS II protein was purified to homogeneity, and 333 residues (85%) of the amino acid sequence were determined by automated Edman degradation [2].
  • SVS II affects the kinetics of actin polymerization in the same way as do barbed end capping proteins [3].
  • Monospecific polyclonal antibodies directed against the N-terminus of actin cross-react with SVS II, but there is no cross-reaction by a monoclonal antibody directed against a C-terminal epitope on actin [3].
  • Rat seminal-vesicle secretory protein SVS II binds DNA with a preference for the 5' regulatory region of secretory protein SVS IV gene: co-isolation with components of the nuclear matrix [4].
  • SVS II binding to SVS IV-7S DNA was greater than its binding to either a comparable fragment of the C3 gene or linearized pUC-19 plasmid, and it was not eliminated by a 100-fold competition [4].

Anatomical context of Svs2

  • When seminal-vesicle fluid was mixed with rat liver, some SVS II co-isolated with the nuclear-matrix proteins, indicating that nonspecific interactions contribute to its association with the nucleoskeleton [4].
  • The secreted polypeptide is a protein of Mr 38442 and is similar in sequence but smaller than the major clot-forming protein of rat semen, SVS II [5].
  • However, these interactions may not represent the intracellular behavior of SVS II in seminal-vesicle epithelium [4].
  • The subcellular distribution of both proteins was clearly different: SVS II was exclusively confined to the electron dense core of the secretory vacuoles, while SVS IV was detected only in the clear halo surrounding the central granule [6].
  • Using an antibody against the SVS II polypeptide from rat seminal vesicles, an intrinsic immunoreactive protein was detected in the principal piece of the sperm tail as well as an extrinsic protein (presumably secreted by the epididymis) on the sperm head [7].

Associations of Svs2 with chemical compounds


Analytical, diagnostic and therapeutic context of Svs2


  1. Identification of low density lipoprotein receptor-related protein-2/megalin as an endocytic receptor for seminal vesicle secretory protein II. Ranganathan, S., Knaak, C., Morales, C.R., Argraves, W.S. J. Biol. Chem. (1999) [Pubmed]
  2. Structural characterization of the rat seminal vesicle secretion II protein and gene. Harris, S.E., Harris, M.A., Johnson, C.M., Bean, M.F., Dodd, J.G., Matusik, R.J., Carr, S.A., Crabb, J.W. J. Biol. Chem. (1990) [Pubmed]
  3. SVS II--an androgen-dependent actin-binding glycoprotein in rat semen. Seitz, J., Keppler, C., Aumüller, G., Polzar, B., Mannherz, H.G. Eur. J. Cell Biol. (1992) [Pubmed]
  4. Rat seminal-vesicle secretory protein SVS II binds DNA with a preference for the 5' regulatory region of secretory protein SVS IV gene: co-isolation with components of the nuclear matrix. Horton, M.J., Getzenberg, R.H. J. Androl. (1999) [Pubmed]
  5. The cloning of a rapidly evolving seminal-vesicle-transcribed gene encoding the major clot-forming protein of mouse semen. Lundwall, A. Eur. J. Biochem. (1996) [Pubmed]
  6. Immunoelectron microscopic evidence for different compartments in the secretory vacuoles of the rat seminal vesicles. Aumüller, G., Seitz, J. Histochem. J. (1986) [Pubmed]
  7. Immunological relationships between specific sperm proteins and secretory polypeptides from seminal vesicles. Seitz, J., Enderle-Schmitt, U., Scheit, K.H., Aumüller, G. Acta Histochem. Suppl. (1989) [Pubmed]
  8. Localization of intrinsic and extrinsic SVS II immunoreactivity in rat spermatozoa. Seitz, J., Aumüller, G. Andrologia (1992) [Pubmed]
  9. Instructive induction of prostate growth and differentiation by a defined urogenital sinus mesenchyme. Timms, B.G., Lee, C.W., Aumüller, G., Seitz, J. Microsc. Res. Tech. (1995) [Pubmed]
WikiGenes - Universities