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Jak3  -  Janus kinase 3

Rattus norvegicus

Synonyms: JAK-3, Tyrosine-protein kinase JAK3
 
 
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High impact information on Jak3

  • Analysis of T cell lysates by immunoprecipitation with specific Abs and subsequent immunoblotting indicated marked reduction of tyrosine phosphorylation of Jak3 and STAT5 mediated by NO [1].
  • Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway [1].
  • The Janus kinase family of protein tyrosine kinases constitutes a novel type of signal transduction pathway activated in response to a wide variety of polypeptide ligands and has four known members: JAK1, JAK2, JAK3, and Tyk2 [2].
  • Transfection with either JAK1, JAK2, or JAK3 increased basal transcription through both the PRE and sis-inducible element [3].
  • Primary microglia and BV-2 cells expressed identical Jak/STATs: Jakl, Jak2, Jak3, Tyk2, STAT1alpha/beta, STAT3, STAT5A, STAT5B, and STAT6 [4].
 

Biological context of Jak3

  • Southern analysis revealed that JAK3 is a single copy gene and well conserved in the vertebral genome [5].
  • JAK3 was identified by RT-PCR of rat mesangial cells using degenerate oligonucleotide primers, and a full-length clone was isolated from a rat spleen cDNA library [5].
 

Anatomical context of Jak3

  • In bone marrow-derived mast cells (BMMCs) from Jak3-deficient (Jak3-/-) mice, degranulation and activation of MAPKs were induced by the antigen in almost the same extent as in BMMCs from wild-type mice [6].
  • Also, colocalization of Jak3 and STAT-1 in the proximal ends of the ameloblasts and the cells of the stratum intermedium predicts the location of the interleukin-7 receptor in those locations [7].
  • Jak1, Tyk2 and STAT-1, but not Jak2 or Jak3, stain was seen in the odontoblasts [7].
 

Associations of Jak3 with chemical compounds

 

Other interactions of Jak3

  • Five minutes before opioid or SB21 treatment, some rats received the putative JAK2 inhibitor AG-490 (3 mg/kg) or the putative JAK3 inhibitor ZM-449829 (3 mg/kg) [9].
 

Analytical, diagnostic and therapeutic context of Jak3

References

  1. Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway. Bingisser, R.M., Tilbrook, P.A., Holt, P.G., Kees, U.R. J. Immunol. (1998) [Pubmed]
  2. Insulin induces tyrosine phosphorylation of JAK2 in insulin-sensitive tissues of the intact rat. Saad, M.J., Carvalho, C.R., Thirone, A.C., Velloso, L.A. J. Biol. Chem. (1996) [Pubmed]
  3. Interactions among Janus kinases and the prolactin (PRL) receptor in the regulation of a PRL response element. Gao, J., Hughes, J.P., Auperin, B., Buteau, H., Edery, M., Zhuang, H., Wojchowski, D.M., Horseman, N.D. Mol. Endocrinol. (1996) [Pubmed]
  4. Signal transduction pathways induced by GM-CSF in microglia: significance in the control of proliferation. Liva, S.M., Kahn, M.A., Dopp, J.M., de Vellis, J. Glia (1999) [Pubmed]
  5. Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases. Takahashi, T., Shirasawa, T. FEBS Lett. (1994) [Pubmed]
  6. Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner. Linwong, W., Hirasawa, N., Aoyama, S., Hamada, H., Saito, T., Ohuchi, K. Br. J. Pharmacol. (2005) [Pubmed]
  7. The immunohistochemical localization of signal-transduction pathway components Jak1, Jak2, Jak3, Tyk2 and STAT-1 during early enamel and dentine formation in rat molars. Tanase, S., Bawden, J.W. Arch. Oral Biol. (1996) [Pubmed]
  8. Changes in DNA binding pattern of transcription factor YY1 in neuronal degeneration. Korhonen, P., Kyrylenko, S., Suuronen, T., Salminen, A. Neurosci. Lett. (2005) [Pubmed]
  9. The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta. Gross, E.R., Hsu, A.K., Gross, G.J. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  10. Inhibition of Jak3 tyrosine kinase by PNU156804 blocks rat heart allograft rejection. Wang, M., Kirken, R., Behbod, F., Erwin-Cohen, R., Stepkowski, S.M., Kahan, B.D. Transplant. Proc. (2001) [Pubmed]
  11. Selective upregulation of cytokine receptor subchain and their intracellular signalling molecules after peripheral nerve injury. Yao, G.L., Kato, H., Khalil, M., Kiryu, S., Kiyama, H. Eur. J. Neurosci. (1997) [Pubmed]
  12. Peripheral but not central axotomy induces changes in Janus kinases (JAK) and signal transducers and activators of transcription (STAT). Schwaiger, F.W., Hager, G., Schmitt, A.B., Horvat, A., Hager, G., Streif, R., Spitzer, C., Gamal, S., Breuer, S., Brook, G.A., Nacimiento, W., Kreutzberg, G.W. Eur. J. Neurosci. (2000) [Pubmed]
 
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