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Gene Review

ste6  -  guanyl-nucleotide exchange factor Ste6

Schizosaccharomyces pombe 972h-

 
 
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High impact information on ste6

  • The ste6 gene of Schizosaccharomyces pombe encodes a putative GDP-GTP exchange factor for the ras1 gene product [1].
  • Furthermore, mutants in which the Ras1 protein is activated have higher basal and induced levels of ste6 gene expression than wild-type cells [1].
  • The ste10 and ste6 genes are located in the right arms of chromosomes II and III, respectively, the former 4 cM distal of trp1 and the latter 1 cM proximal or distal of trp3 [2].
  • The mutant alleles of ste1 and ste9 lead to a defect in both conjugation and meiosis, whereas those of ste6 and ste10 affect mating only [2].
  • P factor production was still possible in class I ste mutants (ste5, ste6 and ste10), which also allow meiosis in diploid strains [3].

References

  1. Transcriptional regulation of a Ras nucleotide-exchange factor gene by extracellular signals in fission yeast. Hughes, D.A., Yabana, N., Yamamoto, M. J. Cell. Sci. (1994) [Pubmed]
  2. Sterile UGA nonsense mutants of fission yeast. Leupold, U., Sipiczki, M. Curr. Genet. (1991) [Pubmed]
  3. Pheromone production and response in sterile mutants of fission yeast. Leupold, U., Sipiczki, M., Egel, R. Curr. Genet. (1991) [Pubmed]
 
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