High impact information on ppb1

• This drug effect was enhanced in stst1 null mutant, which was hypersensitive to various drugs and cations. ppb1 null was not affected by cyclosporin A, consistent with the hypothesis that ppb1 is its target [1].
• The cell polarity control was impaired, causing branched cells. ppb1 null was virtually sterile [1].
• These phenotypes were rescued by a plasmid carrying the ppb1+ gene [1].
• Overexpression of ppb1+ caused anomalies in cell and nuclear shape, microtubule arrays and spindle pole body positioning in interphase cells [1].
• Thus the ppb1+ gene appears to be involved in cytokinesis, mating, transport, nuclear and spindle pole body positioning, and cell shape [1].

References