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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

mad2  -  spindle checkpoint protein Mad2

Schizosaccharomyces pombe 972h-

 
 
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High impact information on mad2

  • We have isolated mad2, a spindle checkpoint component in fission yeast, and shown that mad2 overexpression activates the checkpoint and causes a cell cycle arrest at the metaphase-to-anaphase transition [1].
  • Spindle checkpoint signaling requires the mis6 kinetochore subcomplex, which interacts with mad2 and mitotic spindles [2].
  • S. pombe mad2 mutant cells were compromised in their ability to mate upon removal of TBZ, indicating that in fission yeast, in the absence of microtubules, Mad2 is also required to maintain mating competence [3].
 

Biological context of mad2

  • In addition to the observation that mad2-induced arrest can be partially relieved by mitosis-promoting factor inactivation, we present genetic evidence consistent with the hypothesis that the spindle checkpoint imposes a cell cycle arrest by inhibiting APC-dependent proteolysis [1].

References

  1. The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex. He, X., Patterson, T.E., Sazer, S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Spindle checkpoint signaling requires the mis6 kinetochore subcomplex, which interacts with mad2 and mitotic spindles. Saitoh, S., Ishii, K., Kobayashi, Y., Takahashi, K. Mol. Biol. Cell (2005) [Pubmed]
  3. Conjugation in S. pombe: identification of a microtubule-organising centre, a requirement for microtubules and a role for Mad2. Petersen, J., Heitz, M.J., Hagan, I.M. Curr. Biol. (1998) [Pubmed]
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