High impact information on cdc14

• In Schizosaccharomyces pombe, the sid genes (cdc7, cdc11, cdc14, spg1, sid1, sid2 and sid4) define a signaling pathway that regulates septation and cytokinesis [1].
• The role of the sid1p kinase and cdc14p in regulating the onset of cytokinesis in fission yeast [1].
• If formation of the division septum is prevented by inactivation of either cdc14 or cdc15, p120cdc7 overproduction does not interfere with other events in the mitotic cell cycle [2].
• Schizosaccharomyces pombe skp1+ encodes a protein kinase related to mammalian glycogen synthase kinase 3 and complements a cdc14 cytokinesis mutant [3].
• The Schizosaccharomyces pombe cdc14 gene is required for septum formation and can also inhibit nuclear division [4].

Biological context of cdc14

• A null allele of the cdc14 gene shows that the gene is essential for septum formation and completion of the cell-division cycle [4].
• 67 393 bp of contiguous DNA located between markers cdc18 and cdc14 on the right arm of fission yeast chromosome II has been sequenced as part of the European Union Schizosaccharomyces pombe genome sequencing project [5].

Other interactions of cdc14

• Elevated expression of sce3 increases the steady-state level of cdc14 mRNA [6].
• Our data suggest that the products of the cdc7, cdc11, cdc14 and cdc16 genes interact [7].

References