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Gene Review

skp1  -  SCF ubiquitin ligase complex subunit Skp1

Schizosaccharomyces pombe 972h-

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High impact information on SPBC409.05


Biological context of SPBC409.05

  • RESULTS: We demonstrate that multiple CSN subunits control Ned8p modification of Pcu3p, another fission yeast cullin, which, in complex with the RING domain protein Pip1p, forms a ubiquitin ligase that functions in cellular stress response [6].
  • Here we discuss the conserved yet divergent mechanisms of replication control employed in yeast and metazoan species, including a perspective on the newly uncovered role of the CUL-4 ubiquitin ligase as a central regulator of DNA replication in the nematode Caenorhabditis elegans [7].

Anatomical context of SPBC409.05

  • The morphological sph1 mutant is resistant to papulacandin B, and its cell wall contains less glycoprotein II (but not less glycoprotein I) than the parental wild-type strain, although glycoprotein II is still synthesized and released into the growth medium [8].

Associations of SPBC409.05 with chemical compounds


Other interactions of SPBC409.05


Analytical, diagnostic and therapeutic context of SPBC409.05

  • Interestingly, cells deleted for the essential pof6 gene display a similar cell separation defect noted in skp1 mutants, and Pof6 localizes to septa and cell tips [12].


  1. Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase. Liu, C., Poitelea, M., Watson, A., Yoshida, S.H., Shimoda, C., Holmberg, C., Nielsen, O., Carr, A.M. EMBO J. (2005) [Pubmed]
  2. Arabidopsis has two redundant Cullin3 proteins that are essential for embryo development and that interact with RBX1 and BTB proteins to form multisubunit E3 ubiquitin ligase complexes in vivo. Figueroa, P., Gusmaroli, G., Serino, G., Habashi, J., Ma, L., Shen, Y., Feng, S., Bostick, M., Callis, J., Hellmann, H., Deng, X.W. Plant Cell (2005) [Pubmed]
  3. Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome. Bondar, T., Kalinina, A., Khair, L., Kopanja, D., Nag, A., Bagchi, S., Raychaudhuri, P. Mol. Cell. Biol. (2006) [Pubmed]
  4. Role of Hcn1 and Its Phosphorylation in Fission Yeast Anaphase-promoting Complex/Cyclosome Function. Yoon, H.J., Feoktistova, A., Chen, J.S., Jennings, J.L., Link, A.J., Gould, K.L. J. Biol. Chem. (2006) [Pubmed]
  5. Comparative genomics of the RBR family, including the Parkinson's disease-related gene parkin and the genes of the ariadne subfamily. Marín, I., Ferrús, A. Mol. Biol. Evol. (2002) [Pubmed]
  6. The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p. Zhou, C., Seibert, V., Geyer, R., Rhee, E., Lyapina, S., Cope, G., Deshaies, R.J., Wolf, D.A. BMC Biochem. (2001) [Pubmed]
  7. Preventing DNA re-replication--divergent safeguards in yeast and metazoa. Feng, H., Kipreos, E.T. Cell Cycle (2003) [Pubmed]
  8. Glycoprotein molecules in the walls of Schizosaccharomyces pombe wild-type cells and a morphologically altered mutant resistant to papulacandin B. Font de Mora, J., Valentín, E., Herrero, E., Sentandreu, R. J. Gen. Microbiol. (1990) [Pubmed]
  9. Regulation of the cadmium stress response through SCF-like ubiquitin ligases: comparison between Saccharomyces cerevisiae, Schizosaccharomyces pombe and mammalian cells. Baudouin-Cornu, P., Labarre, J. Biochimie (2006) [Pubmed]
  10. The pub1 E3 ubiquitin ligase negatively regulates leucine uptake in response to NH(4)(+) in fission yeast. Karagiannis, J., Saleki, R., Young, P.G. Curr. Genet. (1999) [Pubmed]
  11. Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo-complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase. Kominami, K., Ochotorena, I., Toda, T. Genes Cells (1998) [Pubmed]
  12. Skp1 and the F-box protein Pof6 are essential for cell separation in fission yeast. Hermand, D., Bamps, S., Tafforeau, L., Vandenhaute, J., Mäkelä, T.P. J. Biol. Chem. (2003) [Pubmed]
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