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Gene Review:

ste13 - ATP-dependent RNA helicase Ste13

Schizosaccharomyces pombe 972h-

Maekawa, H. et al., Molnar, M. et al.

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High impact information on ste13

The ste13+ gene encoding a putative RNA helicase is essential for nitrogen starvation-induced G1 arrest and initiation of sexual development in the fission yeast Schizosaccharomyces pombe [1].
Point mutations introduced into these consensus motifs abolished the ste13+ functions [1].
We have used functional complementation to clone the ste13+ gene from an S. pombe genomic library and show that its disruption is not lethal, indicating that, while the gene is required for sexual development, it is not essential for cell growth [1].
Since it turned out to be allelic with the hitherto unmapped ral2, its linkage with ste13 localizes ral2 on the right arm of chromosome II [2].

References

The ste13+ gene encoding a putative RNA helicase is essential for nitrogen starvation-induced G1 arrest and initiation of sexual development in the fission yeast Schizosaccharomyces pombe. Maekawa, H., Nakagawa, T., Uno, Y., Kitamura, K., Shimoda, C. Mol. Gen. Genet. (1994) [Pubmed]
Two novel genes involved in the sexual development of Schizosaccharomyces pombe. Molnar, M., Sipiczki, M. Curr. Genet. (1995) [Pubmed]

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