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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

rpb2  -  RNA polymerase II complex subunit Rpb2

Schizosaccharomyces pombe 972h-

 
 
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High impact information on rpb2

  • To understand the differential roles of two pathways, we examined strand-specific damage removal at the myo2 and rpb2 loci [1].
  • The protein-to-mRNA ratio or the translation efficiency is low for the rpb1, rpb2, rpb3 and rpb11 genes, encoding the homologues of subunits beta', beta, alpha and alpha, respectively, of the prokaryotic RNA polymerase core enzyme [2].
  • When these mutant rpb2 alleles were expressed in an rpb2-disrupted S. pombe strain, all the mutants grew as well as the wild-type parent and did not show any clear defective phenotypes [3].

References

  1. Transcription dependence and the roles of two excision repair pathways for UV damage in fission yeast Schizosaccharomyces pombe. Yasuhira, S., Morimyo, M., Yasui, A. J. Biol. Chem. (1999) [Pubmed]
  2. Transcription organization and mRNA levels of the genes for all 12 subunits of the fission yeast RNA polymerase II. Sakurai, H., Ishihama, A. Genes Cells (2001) [Pubmed]
  3. Mutational analysis of the RNase-like domain in subunit 2 of fission yeast RNA polymerase II. Kawagishi-Kobayashi, M., Yamamoto, M., Ishihama, A. Mol. Gen. Genet. (1996) [Pubmed]
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