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Gene Review:

rqh1 - RecQ type DNA helicase Rqh1

Schizosaccharomyces pombe 972h-

Synonyms: hus2, rad12, rec9

Doe, C.L. et al., Freyer, G.A. et al., Ahmad, F. et al., Yonemasu, R. et al.

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Disease relevance of hus2

The resolvase partially complements the UV and hydroxyurea hypersensitivity and associated aberrant mitoses of an rqh1(-) mutant [1].

High impact information on hus2

Significantly, overexpression of the resolvase in wild-type cells partly mimics the loss of viability, hyper-recombination and 'cut' phenotype of an rqh1(-) mutant [1].
When the rad12-502 mutant was crossed with the NER rad13-A mutant, the resulting double mutant was much more sensitive to UV radiation than either single mutant, demonstrating that the rad12 gene product functions in a DNA repair pathway distinct from NER [2].
In contrast to a previous report, our genetic analysis showed that rad12 and uvde are not the same gene [3].
In the fission yeast Schizosaccharomyces pombe, disruption of the rqh1(+) gene, which encodes the single Sz. pombe RecQ-related helicase, causes cells to display reduced viability and elevated levels of chromosome loss [4].

References

Partial suppression of the fission yeast rqh1(-) phenotype by expression of a bacterial Holliday junction resolvase. Doe, C.L., Dixon, J., Osman, F., Whitby, M.C. EMBO J. (2000) [Pubmed]
An alternative eukaryotic DNA excision repair pathway. Freyer, G.A., Davey, S., Ferrer, J.V., Martin, A.M., Beach, D., Doetsch, P.W. Mol. Cell. Biol. (1995) [Pubmed]
Characterization of the alternative excision repair pathway of UV-damaged DNA in Schizosaccharomyces pombe. Yonemasu, R., McCready, S.J., Murray, J.M., Osman, F., Takao, M., Yamamoto, K., Lehmann, A.R., Yasui, A. Nucleic Acids Res. (1997) [Pubmed]
Helicase activity is only partially required for Schizosaccharomyces pombe Rqh1p function. Ahmad, F., Kaplan, C.D., Stewart, E. Yeast (2002) [Pubmed]

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