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Gene Review:

rad32 - Rad32 nuclease

Schizosaccharomyces pombe 972h-

Tavassoli, M. et al., Prudden, J. et al.

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High impact information on rad32

We found that the homologous recombination (HR) genes rhp51(+), rad22A(+), rad32(+) and the nucleotide excision repair gene rad16(+) were required for efficient interchromosomal gene conversion [1].
The rad32 gene has been cloned by complementation of the UV sensitive phenotype [2].

Analytical, diagnostic and therapeutic context of rad32

Pulsed field gel electrophoresis of DNA from irradiated cells indicates that the rad32 mutant, in comparison to wild type cells, has decreased ability to repair DNA double strand breaks [2].

References

Pathway utilization in response to a site-specific DNA double-strand break in fission yeast. Prudden, J., Evans, J.S., Hussey, S.P., Deans, B., O'Neill, P., Thacker, J., Humphrey, T. EMBO J. (2003) [Pubmed]
Cloning and characterisation of the Schizosaccharomyces pombe rad32 gene: a gene required for repair of double strand breaks and recombination. Tavassoli, M., Shayeghi, M., Nasim, A., Watts, F.Z. Nucleic Acids Res. (1995) [Pubmed]

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