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Gene Review

cdc3  -  profilin

Schizosaccharomyces pombe 972h-

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High impact information on cdc3

  • Patches move more slowly or stop when actin polymerization is attenuated by Latrunculin A or in arp3 and cdc3 (profilin) mutants [1].
  • One class of cell division mutants (cdc), the late septation mutants, defines four genes: cdc3, cdc4, cdc8, and cdc12 (Nurse, P., P. Thuriaux, and K. Nasmyth. 1976. Mol. & Gen. Genet. 146:167-178) [2].
  • The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis [3].
  • Loss of Ssp1 function inhibits actin relocalization during osmotic stress, in cdc3 and cdc8 mutant backgrounds, and in the presence of latrunculin A, implicating Ssp1 in promotion of actin depolymerization [4].


  1. Role of actin polymerization and actin cables in actin-patch movement in Schizosaccharomyces pombe. Pelham, R.J., Chang, F. Nat. Cell Biol. (2001) [Pubmed]
  2. Schizosaccharomyces pombe cdc4+ gene encodes a novel EF-hand protein essential for cytokinesis. McCollum, D., Balasubramanian, M.K., Pelcher, L.E., Hemmingsen, S.M., Gould, K.L. J. Cell Biol. (1995) [Pubmed]
  3. The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis. Balasubramanian, M.K., Hirani, B.R., Burke, J.D., Gould, K.L. J. Cell Biol. (1994) [Pubmed]
  4. Ssp1 promotes actin depolymerization and is involved in stress response and new end take-off control in fission yeast. Rupes, I., Jia, Z., Young, P.G. Mol. Biol. Cell (1999) [Pubmed]
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