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Gene Review:

gdh - glutamate dehydrogenase

Porphyromonas gingivalis W83

Gharbia, S.E. et al., Joe, A. et al., Takahashi, N. et al.

Takahashi, Sato, Yamada,

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Disease relevance of gdh

The gdh gene showed high homology (78.3%) with that of Clostridium symbiosum [1].
Nucleotide sequence of a Porphyromonas gingivalis gene encoding a surface-associated glutamate dehydrogenase and construction of a glutamate dehydrogenase-deficient isogenic mutant [2].

High impact information on gdh

Glutamate is deaminated and oxidized to succinyl-coenzyme A (CoA) by glutamate dehydrogenase and 2-oxoglutarate oxidoreductase [3].
The gdh gene comprises an open reading frame of 1,335 base pairs that encodes a 49,000-M(r) protein of 445 amino acids [1].
Herein we report the molecular aspects of two such enzymes, the cysteine proteinase gingivain and NAD-dependent glutamate dehydrogenase of Porphyromonas gingivalis [1].

References

Molecular analysis of surface-associated enzymes of Porphyromonas gingivalis. Gharbia, S.E., Shah, H.N. Clin. Infect. Dis. (1995) [Pubmed]
Nucleotide sequence of a Porphyromonas gingivalis gene encoding a surface-associated glutamate dehydrogenase and construction of a glutamate dehydrogenase-deficient isogenic mutant. Joe, A., Murray, C.S., McBride, B.C. Infect. Immun. (1994) [Pubmed]
Metabolic pathways for cytotoxic end product formation from glutamate- and aspartate-containing peptides by Porphyromonas gingivalis. Takahashi, N., Sato, T., Yamada, T. J. Bacteriol. (2000) [Pubmed]

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