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Psmc2  -  proteasome (prosome, macropain) 26S...

Rattus norvegicus

Synonyms: 26S protease regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, Mss1, Proteasome 26S subunit ATPase 2, Protein MSS1
 
 
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High impact information on Psmc2

  • Protein microsequencing and Western blotting identified all the remaining proteasomal ATPases (MSS1, TBP1, TBP7, and SUG2) in the TIP preparations [1].
  • In order to identify which proteasomal subunits were regulated during differentiation, we examined the concentrations of two 20S core subunits (C8 and C9) and three 22S ATPases (MSS1, S4 and TBP1) during differentiation [2].
  • The mRNA levels for all studied subunits increased in unweighted rats, and analysis of MSS1 mRNA distribution profile in polyribosomes showed that this subunit entered active translation [3].
  • Torbafylline, a xanthine derivative which inhibits tumor necrosis factor production, prevented the activation of protein breakdown and the increased expression of 20S proteasome subunits in cancer rats, without reducing the elevated MSS1 mRNA levels [3].

References

  1. Multiple mammalian proteasomal ATPases, but not proteasome itself, are associated with TATA-binding protein and a novel transcriptional activator, TIP120. Makino, Y., Yoshida, T., Yogosawa, S., Tanaka, K., Muramatsu, M., Tamura, T.A. Genes Cells (1999) [Pubmed]
  2. Evidence for the participation of the proteasome and calpain in early phases of muscle cell differentiation. Ueda, Y., Wang, M.C., Ou, B.R., Huang, J., Elce, J., Tanaka, K., Ichihara, A., Forsberg, N.E. Int. J. Biochem. Cell Biol. (1998) [Pubmed]
  3. Expression of subunits of the 19S complex and of the PA28 activator in rat skeletal muscle. Attaix, D., Taillandier, D., Combaret, L., Rallière, C., Larbaud, D., Aurousseau, E., Tanaka, K. Mol. Biol. Rep. (1997) [Pubmed]
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