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Pcmt1  -  protein-L-isoaspartate (D-aspartate) O...

Rattus norvegicus

Synonyms: L-isoaspartyl protein carboxyl methyltransferase, PIMT, Protein L-isoaspartyl/D-aspartyl methyltransferase, Protein-L-isoaspartate(D-aspartate) O-methyltransferase, Protein-beta-aspartate methyltransferase
 
 
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Disease relevance of Pcmt1

 

Psychiatry related information on Pcmt1

 

High impact information on Pcmt1

  • Fractionation of heads and tails of rat spermatozoa on sucrose gradients indicated that PCM was found exclusively in the tail fraction, whereas MAP was detected both in head and tail fractions [7].
  • The specific activities of PCM in rat spermatozoa from caput and cauda epididymis were similar and lower than that found in testis [7].
  • The presence of all the components of the protein carboxyl-methylation system in spermatozoa and the localization of PCM and some of its substrates in the sperm tail are consistent with their involvement in sperm cell motility [7].
  • Protein carboxyl-methylase (PCM), an enzyme known to be involved in exocytotic secretion and chemotaxis, has been studied in rat and rabbit spermatozoa [7].
  • PCM activity and its substrate methyl acceptor protein(s) (MAP) were demonstrated in the supernate after solubilization of the sperm cell membrane by detergent (Triton X-100) [7].
 

Chemical compound and disease context of Pcmt1

 

Biological context of Pcmt1

  • Inhibition of PIMT/Tgs1 expression by siRNA in HeLa cells resulted in an increase in the percentage of cells in G2/M phases [13].
  • The EPC decayed exponentially in the presence of PCP and PCM, with a shortened time constant of decay that was less dependent on membrane potential than control [14].
  • To date, cellular adaptive responses and gene expression associated with PCM remain poorly understood [15].
  • Starved and PCM rats, in contrast, had decreased oxygen consumption compared to the freely-fed controls [16].
  • Starved and protein-calorie malnourished (PCM) control animals had a similar response of heart rate, left ventricular peak pressure and contractility as the tumor-bearing group [16].
 

Anatomical context of Pcmt1

 

Associations of Pcmt1 with chemical compounds

  • A protein methylesterase that hydrolyzes methyl ester bonds created by PCM was demonstrated in rabbit but not in rat spermatozoa [7].
  • PCP and PCM caused only a 20% decrease of the amplitude of the iontophoretically evoked acetylcholine potential, which was significantly different from that induced by the desensitizing alkaloid perhydrohistrionicotoxin [14].
  • In contrast, Listeria-stimulated alveolar macrophages from the PCM group exhibited a marked shift in arachidonic acid metabolism, with impaired production of leukotriene B4 and enhanced release of thromboxane B2 and PGE2 [1].
  • Protein carboxyl-methylase (PCM), the enzyme that transfers methyl groups from S-adenosyl-methionine to free carboxyl groups on proteins, is highly localized in testes [19].
  • This suggests that in slices prepared from normal rats endogenous dopamine (DA) released during slice preparation and incubation masks the effects produced by exogenously administered dopamine agonists on protein carboxyl methylase (PCM) activity [20].
 

Analytical, diagnostic and therapeutic context of Pcmt1

  • In sections taken from the posterior hypothalamic area of rats prepared in a conventional way for electron microscopy, distinct populations of large cells can be observed in TM, CM, and PCM displaying the same set of ultrastructural characteristics as the HDC-immunoreactive neurons [21].
  • Periodically, a single unit dose of either phencyclidine (0.5 mg/kg), ketamine (4 mg/kg) or 1-(1-phenylcyclohexyl)morpholine (PCM 4 mg/kg) was substituted for ketamine, while the cortical EEG was recorded [22].
  • Northern blot analysis showed that hepatic P450 1A2, 2C11, and 3A1/2 mRNAs were significantly decreased in the state of PCM [23].
  • After 5 and 7 weeks, the numbers of lavaged AM per gram body weight of rats were much higher in the PCM group than in the control group [24].
  • At appropriate times, rats from control (20% casein diet) and PCM groups were killed and alveolar macrophages (AM) were obtained by bronchoalveolar lavage [24].

References

  1. Alveolar macrophage function in rats with severe protein calorie malnutrition. Arachidonic acid metabolism, cytokine release, and antimicrobial activity. Skerrett, S.J., Henderson, W.R., Martin, T.R. J. Immunol. (1990) [Pubmed]
  2. Myocardial inotropic responses and adrenoceptors in protein-deficient rats. Benfey, B.G., Varma, D.R., Yue, T.L. Br. J. Pharmacol. (1983) [Pubmed]
  3. Isoaspartate in ribosomal protein S11 of Escherichia coli. David, C.L., Keener, J., Aswad, D.W. J. Bacteriol. (1999) [Pubmed]
  4. Environmental co-regulation of substance P, somatostatin and neurotransmitter synthesizing enzymes in cultured sympathetic neurons. Kessler, J.A. Brain Res. (1984) [Pubmed]
  5. Pharmacokinetics of intravenous and oral DA-8159, a new erectogenic, in rats with protein-calorie malnutrition. Shim, H.J., Kim, Y.C., Lee, J.H., Ahn, B.O., Kwon, J.W., Kim, W.B., Lee, I., Lee, M.G. J. Pharm. Pharmacol. (2004) [Pubmed]
  6. The effects of severe protein-calorie malnutrition on antibacterial defense mechanisms in the rat lung. Martin, T.R., Altman, L.C., Alvares, O.F. Am. Rev. Respir. Dis. (1983) [Pubmed]
  7. The localization of protein carboxyl-methylase in sperm tails. Bouchard, P., Gagnon, C., Phillips, D.M., Bardin, C.W. J. Cell Biol. (1980) [Pubmed]
  8. Influence of protein-calorie malnutrition on the pharmacokinetics, placental transfer and tissue localization of dexamethasone in rats. Varma, D.R., Yue, T.L. Br. J. Pharmacol. (1984) [Pubmed]
  9. Influence of age, sex, pregnancy and protein-calorie malnutrition on the pharmacokinetics of salicylate in rats. Varma, D.R., Yue, T.L. Br. J. Pharmacol. (1984) [Pubmed]
  10. Effects of cysteine on the pharmacokinetics of oltipraz in rats with protein-calorie malnutrition. Bae, S.K., Yang, S.H., Kim, J.W., Kim, T., Kwon, J.W., Lee, M.G. Journal of pharmaceutical sciences. (2005) [Pubmed]
  11. Influence of protein and calorie malnutrition on the pharmacokinetics and pharmacodynamics of bumetanide in rats. Kim, S.H., Lee, M.G. Journal of pharmaceutical sciences. (1993) [Pubmed]
  12. Effects of protein calorie malnutrition on the pharmacokinetics of ketamine in rats. Williams, M.L., Mager, D.E., Parenteau, H., Gudi, G., Tracy, T.S., Mulheran, M., Wainer, I.W. Drug Metab. Dispos. (2004) [Pubmed]
  13. Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus. Enünlü, I., Pápai, G., Cserpán, I., Udvardy, A., Jeang, K.T., Boros, I. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  14. Voltage- and time-dependent effects of phencyclidines on the endplate current arise from open and closed channel blockade. Aguayo, L.G., Witkop, B., Albuquerque, E.X. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  15. Prevention of c-Jun/activator protein-1 activation and microsomal epoxide hydrolase induction in the rat liver by cysteine during protein-calorie malnutrition. Cho, M.K., Kim, Y.G., Lee, M.G., Kim, S.G. Biochem. Pharmacol. (2001) [Pubmed]
  16. Cardiac sensitivity and responsiveness to beta-adrenergic stimulation in experimental cancer and undernutrition. Drott, C., Waldenström, A., Lundholm, K. J. Mol. Cell. Cardiol. (1987) [Pubmed]
  17. Tissue-specific expression of isoaspartyl protein carboxyl methyltransferase gene in rat brain and testis. Mizobuchi, M., Murao, K., Takeda, R., Kakimoto, Y. J. Neurochem. (1994) [Pubmed]
  18. Kinetics of mobilization of neutrophils and their marrow pool in protein-calorie deficiency. Suda, A.K., Mathur, M., Deo, K., Deo, M.G. Blood (1976) [Pubmed]
  19. Protein carboxyl-methylation in rat testes: a study of inherited and X-ray-induced seminiferous tubule failure. Gagnon, C., Axelrod, J., Musto, N., Dym, M., Bardin, C.W. Endocrinology (1979) [Pubmed]
  20. Dopamine autoreceptor stimulation increases protein carboxyl methylation in striatal slices. Wolf, M.E., Roth, R.H. J. Neurochem. (1985) [Pubmed]
  21. Histaminergic neurons in the rat brain: correlative immunocytochemistry, Golgi impregnation, and electron microscopy. Wouterlood, F.G., Sauren, Y.M., Steinbusch, H.W. J. Comp. Neurol. (1986) [Pubmed]
  22. Cortical EEG changes during the self-administration of phencyclinoids. Marquis, K.L., Gussio, R., Webb, M.G., Moreton, J.E. Neuropharmacology (1989) [Pubmed]
  23. Suppression of rat hepatic cytochrome P450s by protein-calorie malnutrition: complete or partial restoration by cysteine or methionine supplementation. Cho, M.K., Kim, Y.G., Lee, M.G., Kim, S.G. Arch. Biochem. Biophys. (1999) [Pubmed]
  24. Activation of antitumor properties in alveolar macrophages from protein-calorie malnourished rats. Mutsuura, S., Sone, S., Tsubura, E., Tachibana, K., Kishino, Y. Cancer Immunol. Immunother. (1986) [Pubmed]
 
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