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Gene Review

Crem  -  cAMP responsive element modulator

Rattus norvegicus

Synonyms: cAMP-responsive element modulator
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Disease relevance of Crem

  • Overexpression of CREM-17X in intact islets via adenovirus infection decreased islet insulin mRNA levels and insulin content and resulted in a significant decrease in glucose- or KCl-induced insulin secretion [1].

High impact information on Crem


Biological context of Crem


Anatomical context of Crem


Associations of Crem with chemical compounds


Other interactions of Crem

  • These results suggest that retinoids function as a negative regulator of CREM expression in testes [6].

Analytical, diagnostic and therapeutic context of Crem

  • Northern blot analysis revealed a 5-fold increase in the abundance of CREM-17X mRNA and a concomitant 50% reduction in the insulin mRNA in FFA-treated islets [1].
  • In addition, RT-PCR analysis indicated that ATRA specifically represses the expression of the activator spliced variant of CREM (CREMtau) [6].
  • Consistent with an inhibitory effect of CREM on CRH transcription, chromatin immunoprecipitation assays in cells transfected with ICER I revealed recruitment of CREM by the CRH promoter in conjunction with decreases in Pol II association [5].
  • Using in situ hybridization with a cDNA fragment of the cAMP responsive element modulator (CREM) isoform inducible cAMP early repressor (ICER) we demonstrate a light-induced upregulation of CREM mRNA in rat SCN during the second half of the night [11].
  • Western blot analysis using CREM antibodies confirmed the RNA data [10].


  1. Overexpression of repressive cAMP response element modulators in high glucose and fatty acid-treated rat islets. A common mechanism for glucose toxicity and lipotoxicity? Zhou, Y.P., Marlen, K., Palma, J.F., Schweitzer, A., Reilly, L., Gregoire, F.M., Xu, G.G., Blume, J.E., Johnson, J.D. J. Biol. Chem. (2003) [Pubmed]
  2. Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor. Molina, C.A., Foulkes, N.S., Lalli, E., Sassone-Corsi, P. Cell (1993) [Pubmed]
  3. Pituitary follicle-stimulating hormone (FSH) induces CREM gene expression in Sertoli cells: involvement in long-term desensitization of the FSH receptor. Monaco, L., Foulkes, N.S., Sassone-Corsi, P. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  4. The transcriptional repressor ICER and cAMP-induced programmed cell death. Ruchaud, S., Seité, P., Foulkes, N.S., Sassone-Corsi, P., Lanotte, M. Oncogene (1997) [Pubmed]
  5. Inhibition of corticotrophin-releasing hormone transcription by inducible cAMP-early repressor in the hypothalamic cell line, 4B. Liu, Y., Kalintchenko, N., Sassone-Corsi, P., Aguilera, G. J. Neuroendocrinol. (2006) [Pubmed]
  6. The administration of retinoic acid down-regulates cAMP-responsive element modulator (CREM) mRNA in vitamin A-deficient testes. Matsuda, M., Hyoudou, T., Kadowaki, M., Onuki, K., Masushige, S., Kida, S. Biosci. Biotechnol. Biochem. (2005) [Pubmed]
  7. Inducible cAMP early repressor ICER down-regulation of CREB gene expression in Sertoli cells. Walker, W.H., Daniel, P.B., Habener, J.F. Mol. Cell. Endocrinol. (1998) [Pubmed]
  8. Preservation of spermatogenesis in spinal cord injured rats with exogenous testosterone. Relationship with serum testosterone levels and cellular localization of cAMP responsive element modulator. Huang, H.F., Wang, S., Molina, C.A., Ottenweller, J.E. J. Androl. (2004) [Pubmed]
  9. The inducible isoform of CREM (inducible cAMP early repressor, ICER) is a repressor of CYP19 rat ovarian promoter. Morales, V., Gonzalez-Robayna, I., Hernandez, I., Quintana, J., Santana, P., Ruiz de Galarreta, C.M., Fanjul, L.F. J. Endocrinol. (2003) [Pubmed]
  10. Expression of cAMP-responsive element modulator (CREM) in rat testes following chronic cocaine administration. Li, H., Dunbar, J.C., Dhabuwala, C.B. J. Environ. Pathol. Toxicol. Oncol. (2003) [Pubmed]
  11. Light-induced expression of transcription factor ICER (inducible cAMP early repressor) in rat suprachiasmatic nucleus is phase-restricted. Stehle, J.H., Pfeffer, M., Kühn, R., Korf, H.W. Neurosci. Lett. (1996) [Pubmed]
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