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Gene Review

Ptgfr  -  prostaglandin F receptor

Rattus norvegicus

Synonyms: PGF receptor, PGF2-alpha receptor, Prostaglandin F2-alpha receptor, Prostanoid FP receptor
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Disease relevance of Ptgfr


High impact information on Ptgfr


Biological context of Ptgfr


Anatomical context of Ptgfr


Associations of Ptgfr with chemical compounds


Other interactions of Ptgfr

  • Since PGF2 alpha-receptor content does not coincide with the increase in enzyme activity (maximal receptor content preceded maximal enzyme activity by about 6 days), PGF2 alpha may not be the only direct factor responsible for the induction of ovarian 20 alpha-OH-SDH, to terminate luteal function [15].


  1. Pulmonary hypertension in acute lung injury is due to impaired vasodilation with intact vascular contractility. McIntyre, R.C., Banerjee, A., Agrafojo, J., Fullerton, D.A. J. Surg. Res. (1995) [Pubmed]
  2. Diverse prostaglandin receptors activate distinct signal transduction pathways in rat myometrium. Goureau, O., Tanfin, Z., Marc, S., Harbon, S. Am. J. Physiol. (1992) [Pubmed]
  3. Prostaglandin F2 alpha stimulates hypertrophic growth of cultured neonatal rat ventricular myocytes. Adams, J.W., Migita, D.S., Yu, M.K., Young, R., Hellickson, M.S., Castro-Vargas, F.E., Domingo, J.D., Lee, P.H., Bui, J.S., Henderson, S.A. J. Biol. Chem. (1996) [Pubmed]
  4. Inhibition of collagen synthesis by prostaglandins in the immortalized rat osteoblastic cell line Py1a: structure-activity relations and signal transduction mechanisms. Fall, P.M., Breault, D.T., Raisz, L.G. J. Bone Miner. Res. (1994) [Pubmed]
  5. Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes. Kitanaka, J., Ishibashi, T., Baba, A. J. Neurochem. (1993) [Pubmed]
  6. Expression and localization of the contractile prostaglandin F receptor in pregnant rat myometrium in late gestation, labor, and postpartum. Al-Matubsi, H.Y., Eis, A.L., Brodt-Eppley, J., MacPhee, D.J., Lye, S., Myatt, L. Biol. Reprod. (2001) [Pubmed]
  7. Pregnancy and exogenous steroid treatments modulate the expression of relaxant EP(2) and contractile FP receptors in the rat uterus. Dong, Y.L., Yallampalli, C. Biol. Reprod. (2000) [Pubmed]
  8. Inhibition by the protein kinase C activator 4 beta-phorbol 12-myristate 13-acetate of the prostaglandin F2 alpha-mediated and noradrenaline-mediated but not glucagon-mediated activation of glycogenolysis in rat liver. Püschel, G.P., Miura, H., Neuschäfer-Rube, F., Jungermann, K. Eur. J. Biochem. (1993) [Pubmed]
  9. Failure to detect specific binding sites for prostaglandin F-2 alpha in membrane preparations from rat endometrium. Martel, D., Kennedy, T.G., Monier, M.N., Psychoyos, A. J. Reprod. Fertil. (1985) [Pubmed]
  10. Desensitization of prostaglandin F2 alpha receptor-mediated phosphoinositide hydrolysis in cultured rat astrocytes. Gotoh, M., Kitanaka, J., Hirasawa, Y., Kondo, K., Baba, A. Neurochem. Res. (1994) [Pubmed]
  11. Luteolytic potency of PGD and PGF2 alpha derivatives. Brambaifa, N. Eur. J. Obstet. Gynecol. Reprod. Biol. (1988) [Pubmed]
  12. Immunohistochemical localization of PGF2 alpha receptor in the rat oviduct. Orlicky, D.J., Williams-Skipp, C. Prostaglandins Leukot. Essent. Fatty Acids (1993) [Pubmed]
  13. Prostaglandin E receptor subtypes in smooth muscle: agonist activities of stable prostacyclin analogues. Dong, Y.J., Jones, R.L., Wilson, N.H. Br. J. Pharmacol. (1986) [Pubmed]
  14. Immunohistochemical localization of PGF2 alpha receptor in the rat ovary. Orlicky, D.J., Fisher, L., Dunscomb, N., Miller, G.J. Prostaglandins Leukot. Essent. Fatty Acids (1992) [Pubmed]
  15. Binding of prostaglandin F2 alpha and 20 alpha-hydroxysteroid-dehydrogenase activity of immature rat ovaries throughout pseudopregnancy. Brambaifa, N., Schillinger, E. Prostaglandins, leukotrienes, and medicine. (1984) [Pubmed]
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