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Gene Review

Cd38  -  CD38 molecule

Rattus norvegicus

Synonyms: 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, ...
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Disease relevance of Cd38


High impact information on Cd38


Chemical compound and disease context of Cd38


Biological context of Cd38


Anatomical context of Cd38


Associations of Cd38 with chemical compounds

  • Stimulation of pancreatic acinar cells with CCK or ACh results in exclusive activation of the cytosolic ADP-ribosyl cyclase activity, most likely mediated by cGMP [13].
  • Isoproterenol at 1 microM increased ADP-ribosyl cyclase activity by 1.7-fold in ventricular muscle; this increase was inhibited by propranolol [14].
  • An enzyme from canine spleen previously shown to contain NAD glycohydrolase, ADPR cyclase, and cADPR hydrolase activities also utilized NADP and 2'-P-cADPR as substrates [16].
  • The formation rate of [3H]ADP-ribose from cyclic ADP-ribose by cyclic ADP-ribose hydrolase and/or from NAD+ by NAD glycohydrolase was low and enriched in the cytosolic fraction [17].
  • Thus, the subtype-specific coupling of mGluRs to ADP-ribosyl cyclase via G proteins suggests that some glutamate-evoked neuronal functions are mediated by cADP-ribose [2].

Other interactions of Cd38


Analytical, diagnostic and therapeutic context of Cd38


  1. CD38/ADP-ribosyl cyclase: A new role in the regulation of osteoclastic bone resorption. Sun, L., Adebanjo, O.A., Moonga, B.S., Corisdeo, S., Anandatheerthavarada, H.K., Biswas, G., Arakawa, T., Hakeda, Y., Koval, A., Sodam, B., Bevis, P.J., Moser, A.J., Lai, F.A., Epstein, S., Troen, B.R., Kumegawa, M., Zaidi, M. J. Cell Biol. (1999) [Pubmed]
  2. Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. Higashida, H., Zhang, J.S., Mochida, S., Chen, X.L., Shin, Y., Noda, M., Hossain, K.Z., Hoshi, N., Hashii, M., Shigemoto, R., Nakanishi, S., Fukuda, Y., Yokoyama, S. J. Neurochem. (2003) [Pubmed]
  3. Increase of intracellular Ca(2+) during ischemia/reperfusion injury of heart is mediated by cyclic ADP-ribose. Xie, G.H., Rah, S.Y., Yi, K.S., Han, M.K., Chae, S.W., Im, M.J., Kim, U.H. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  4. Myocardial ischemia and reperfusion reduce the levels of cyclic ADP-ribose in rat myocardium. Ge, Z.D., Li, P.L., Chen, Y.F., Gross, G.J., Zou, A.P. Basic Res. Cardiol. (2002) [Pubmed]
  5. Autoantibodies against CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) that impair glucose-induced insulin secretion in noninsulin- dependent diabetes patients. Ikehata, F., Satoh, J., Nata, K., Tohgo, A., Nakazawa, T., Kato, I., Kobayashi, S., Akiyama, T., Takasawa, S., Toyota, T., Okamoto, H. J. Clin. Invest. (1998) [Pubmed]
  6. Effect of estrogen upon cyclic ADP ribose metabolism: beta-estradiol stimulates ADP ribosyl cyclase in rat uterus. Chini, E.N., de Toledo, F.G., Thompson, M.A., Dousa, T.P. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  7. Extracellular synthesis of cADP-ribose from nicotinamide-adenine dinucleotide by rat cortical astrocytes in culture. Pawlikowska, L., Cottrell, S.E., Harms, M.B., Li, Y., Rosenberg, P.A. J. Neurosci. (1996) [Pubmed]
  8. A cloned rat CD38-homologous protein and its expression in pancreatic islets. Li, Q., Yamada, Y., Yasuda, K., Ihara, Y., Okamoto, Y., Kaisaki, P.J., Watanabe, R., Ikeda, H., Tsuda, K., Seino, Y. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  9. Total synthesis of cyclic ADP-carbocyclic-ribose, a stable mimic of Ca2+-mobilizing second messenger cyclic ADP-ribose. Shuto, S., Fukuoka, M., Manikowsky, A., Ueno, Y., Nakano, T., Kuroda, R., Kuroda, H., Matsuda, A. J. Am. Chem. Soc. (2001) [Pubmed]
  10. Ryanodine receptor subtype 2 encodes Ca2+ oscillations activated by acetylcholine via the M2 muscarinic receptor/cADP-ribose signalling pathway in duodenum myocytes. Fritz, N., Macrez, N., Mironneau, J., Jeyakumar, L.H., Fleischer, S., Morel, J.L. J. Cell. Sci. (2005) [Pubmed]
  11. Chemistry of cyclic ADP-ribose and its analogs. Shuto, S., Matsuda, A. Current medicinal chemistry. (2004) [Pubmed]
  12. Angiotensin II stimulates cyclic ADP-ribose formation in neonatal rat cardiac myocytes. Higashida, H., Zhang, J., Hashii, M., Shintaku, M., Higashida, C., Takeda, Y. Biochem. J. (2000) [Pubmed]
  13. Hormonal control of ADP-ribosyl cyclase activity in pancreatic acinar cells from rats. Sternfeld, L., Krause, E., Guse, A.H., Schulz, I. J. Biol. Chem. (2003) [Pubmed]
  14. Sympathetic potentiation of cyclic ADP-ribose formation in rat cardiac myocytes. Higashida, H., Egorova, A., Higashida, C., Zhong, Z.G., Yokoyama, S., Noda, M., Zhang, J.S. J. Biol. Chem. (1999) [Pubmed]
  15. Estrogen increases CD38 gene expression and leads to differential regulation of adenosine diphosphate (ADP)-ribosyl cyclase and cyclic ADP-ribose hydrolase activities in rat myometrium. Dogan, S., White, T.A., Deshpande, D.A., Murtaugh, M.P., Walseth, T.F., Kannan, M.S. Biol. Reprod. (2002) [Pubmed]
  16. 2'-Phospho-cyclic ADP-ribose, a calcium-mobilizing agent derived from NADP. Vu, C.Q., Lu, P.J., Chen, C.S., Jacobson, M.K. J. Biol. Chem. (1996) [Pubmed]
  17. Membrane-bound form of ADP-ribosyl cyclase in rat cortical astrocytes in culture. Hotta, T., Asai, K., Fujita, K., Kato, T., Higashida, H. J. Neurochem. (2000) [Pubmed]
  18. Endothelin-1-induced contraction of mesenteric small arteries is mediated by ryanodine receptor Ca2+ channels and cyclic ADP-ribose. Giulumian, A.D., Meszaros, L.G., Fuchs, L.C. J. Cardiovasc. Pharmacol. (2000) [Pubmed]
  19. Ectocellular in vitro and in vivo metabolism of cADP-ribose in cerebellum. De Flora, A., Guida, L., Franco, L., Zocchi, E., Pestarino, M., Usai, C., Marchetti, C., Fedele, E., Fontana, G., Raiteri, M. Biochem. J. (1996) [Pubmed]
  20. Synthesis of NAADP and cADPR in mitochondria. Liang, M., Chini, E.N., Cheng, J., Dousa, T.P. Arch. Biochem. Biophys. (1999) [Pubmed]
  21. NADP+-Dependent internalization of recombinant CD38 in CHO cells. Chidambaram, N., Chang, C.F. Arch. Biochem. Biophys. (1999) [Pubmed]
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