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Gene Review

GAGE2C  -  G antigen 2C

Homo sapiens

Synonyms: CT4.2, GAGE-2, GAGE-2C, GAGE2
 
 
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Disease relevance of GAGE2

  • The two genes of the GAGE family that code for this peptide, namely GAGE-1 and GAGE-2, are expressed in a significant proportion of melanomas (24%), sarcomas (25%), non-small cell lung cancers (19%), head and neck tumors (19%), and bladder tumors (12%) [1].

References

  1. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. Van den Eynde, B., Peeters, O., De Backer, O., Gaugler, B., Lucas, S., Boon, T. J. Exp. Med. (1995) [Pubmed]
 
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