The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Ppara  -  peroxisome proliferator activated receptor...

Rattus norvegicus

Synonyms: Nr1c1, Nuclear receptor subfamily 1 group C member 1, PPAR-alpha, Peroxisome proliferator-activated receptor alpha, Ppar
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ppara


Psychiatry related information on Ppara


High impact information on Ppara

  • In addition, we demonstrate that PPAR-alpha and -gamma are expressed in eosinophils and their activation inhibits in vitro chemotaxis and antibody-dependent cellular cytotoxicity [7].
  • BACKGROUND & AIMS: The peroxisome proliferator-activated nuclear receptors (PPAR-alpha, PPAR-beta, and PPAR-gamma), which modulate the expression of genes involved in energy homeostasis, cell cycle, and immune function, may play a role in hepatic stellate cell activation [8].
  • Peroxisome proliferator-activated receptor alpha (PPAR alpha) plays a central role in the cell-specific pleiotropic responses induced by structurally diverse synthetic chemicals designated as peroxisome proliferators [9].
  • Here we report the identification of such a transcriptionally active PPAR alpha-interacting cofactor (PRIC) complex from rat liver nuclear extracts that interacts with full-length PPAR alpha in the presence of ciprofibrate, a synthetic ligand, and leukotriene B(4), a natural ligand [9].
  • TG was high because of underexpression of fatty acid oxidative enzymes and their transcription factor, peroxisome proliferator-activated receptor-alpha [10].

Chemical compound and disease context of Ppara


Biological context of Ppara


Anatomical context of Ppara


Associations of Ppara with chemical compounds


Regulatory relationships of Ppara


Other interactions of Ppara

  • Together, these data indicate that sPLA2-IIA released from mesangial cells by TNF alpha stimulates its own expression via an autocrine loop involving cPLA2 and PPAR alpha [18].
  • There was also a marked increase in Pparg (65%, P < 0.05) and Ppara (91%, P < 0.05) mRNA specifically in the labyrinth zone over the final third of pregnancy [17].
  • Results from this study suggest that alterations in peroxisomal metabolism observed in the senescent liver may be a result of the decline in the availability of RXR alpha receptor, and not the primary PPAR alpha receptor [16].
  • Therefore, chronic PPAR-alpha agonist treatment reduces salt-dependent hypertension produced by ETB receptor blockade in male and female Sprague-Dawley rats [1].
  • Effect of PPAR-alpha and -gamma agonist on the expression of visfatin, adiponectin, and TNF-alpha in visceral fat of OLETF rats [27].

Analytical, diagnostic and therapeutic context of Ppara


  1. Peroxisome proliferator-activated receptor-alpha activation reduces salt-dependent hypertension during chronic endothelin B receptor blockade. Williams, J.M., Zhao, X., Wang, M.H., Imig, J.D., Pollock, D.M. Hypertension (2005) [Pubmed]
  2. Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha). Guzmán, M., Lo Verme, J., Fu, J., Oveisi, F., Blázquez, C., Piomelli, D. J. Biol. Chem. (2004) [Pubmed]
  3. Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48. Lindén, D., Lindberg, K., Oscarsson, J., Claesson, C., Asp, L., Li, L., Gustafsson, M., Borén, J., Olofsson, S.O. J. Biol. Chem. (2002) [Pubmed]
  4. Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism. Holness, M.J., Smith, N.D., Bulmer, K., Hopkins, T., Gibbons, G.F., Sugden, M.C. Biochem. J. (2002) [Pubmed]
  5. PPAR alpha activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II-infused rats. Diep, Q.N., Benkirane, K., Amiri, F., Cohn, J.S., Endemann, D., Schiffrin, E.L. J. Mol. Cell. Cardiol. (2004) [Pubmed]
  6. Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. Proulx, K., Cota, D., Castañeda, T.R., Tschöp, M.H., D'Alessio, D.A., Tso, P., Woods, S.C., Seeley, R.J. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
  7. Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation. Woerly, G., Honda, K., Loyens, M., Papin, J.P., Auwerx, J., Staels, B., Capron, M., Dombrowicz, D. J. Exp. Med. (2003) [Pubmed]
  8. Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells. Hellemans, K., Michalik, L., Dittie, A., Knorr, A., Rombouts, K., De Jong, J., Heirman, C., Quartier, E., Schuit, F., Wahli, W., Geerts, A. Gastroenterology (2003) [Pubmed]
  9. Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Surapureddi, S., Yu, S., Bu, H., Hashimoto, T., Yeldandi, A.V., Kashireddy, P., Cherkaoui-Malki, M., Qi, C., Zhu, Y.J., Rao, M.S., Reddy, J.K. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  10. Lipotoxic heart disease in obese rats: implications for human obesity. Zhou, Y.T., Grayburn, P., Karim, A., Shimabukuro, M., Higa, M., Baetens, D., Orci, L., Unger, R.H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  11. Differential effects of peroxisome proliferator activator receptor-alpha and gamma ligands on intimal hyperplasia after balloon catheter-induced vascular injury in Zucker rats. Desouza, C.V., Murthy, S.N., Diez, J., Dunne, B., Matta, A.S., Fonseca, V.A., McNamara, D.B. J. Cardiovasc. Pharmacol. Ther. (2003) [Pubmed]
  12. Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size. Wayman, N.S., Hattori, Y., McDonald, M.C., Mota-Filipe, H., Cuzzocrea, S., Pisano, B., Chatterjee, P.K., Thiemermann, C. FASEB J. (2002) [Pubmed]
  13. The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver. Galli, A., Pinaire, J., Fischer, M., Dorris, R., Crabb, D.W. J. Biol. Chem. (2001) [Pubmed]
  14. Atorvastatin treatment induced peroxisome proliferator-activated receptor alpha expression and decreased plasma nonesterified fatty acids and liver triglyceride in fructose-fed rats. Roglans, N., Sanguino, E., Peris, C., Alegret, M., Vázquez, M., Adzet, T., Díaz, C., Hernández, G., Laguna, J.C., Sánchez, R.M. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  15. Dietary Conjugated Linoleic Acid Lowered Tumor Necrosis Factor-alpha Content and Altered Expression of Genes Related to Lipid Metabolism and Insulin Sensitivity in the Skeletal Muscle of Zucker Rats. Inoue, N., Nagao, K., Wang, Y.M., Noguchi, H., Shirouchi, B., Yanagita, T. J. Agric. Food Chem. (2006) [Pubmed]
  16. Senescence-associated decline in hepatic peroxisomal enzyme activities corresponds with diminished levels of retinoid X receptor alpha, but not peroxisome proliferator-activated receptor alpha. Chao, C., Youssef, J., Rezaiekhaleigh, M., Birnbaum, L.S., Badr, M. Mech. Ageing Dev. (2002) [Pubmed]
  17. Placental expression of peroxisome proliferator-activated receptors in rat pregnancy and the effect of increased glucocorticoid exposure. Hewitt, D.P., Mark, P.J., Waddell, B.J. Biol. Reprod. (2006) [Pubmed]
  18. Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation. Beck, S., Lambeau, G., Scholz-Pedretti, K., Gelb, M.H., Janssen, M.J., Edwards, S.H., Wilton, D.C., Pfeilschifter, J., Kaszkin, M. J. Biol. Chem. (2003) [Pubmed]
  19. Distribution of mRNAs encoding the peroxisome proliferator-activated receptor alpha, beta, and gamma and the retinoid X receptor alpha, beta, and gamma in rat central nervous system. Cullingford, T.E., Bhakoo, K., Peuchen, S., Dolphin, C.T., Patel, R., Clark, J.B. J. Neurochem. (1998) [Pubmed]
  20. Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells. Ravnskjaer, K., Boergesen, M., Rubi, B., Larsen, J.K., Nielsen, T., Fridriksson, J., Maechler, P., Mandrup, S. Endocrinology (2005) [Pubmed]
  21. PPAR alpha stimulates the rat gastrin-producing cell. Bakke, I., Hammer, T.A., Sandvik, A.K., Waldum, H.L. Mol. Cell. Endocrinol. (2002) [Pubmed]
  22. Differential influences of peroxisome proliferator-activated receptors gamma and -alpha on food intake and energy homeostasis. Larsen, P.J., Jensen, P.B., Sørensen, R.V., Larsen, L.K., Vrang, N., Wulff, E.M., Wassermann, K. Diabetes (2003) [Pubmed]
  23. TNF-alpha downregulates the peroxisome proliferator activated receptor-alpha and the mRNAs encoding peroxisomal proteins in rat liver. Beier, K., Völkl, A., Fahimi, H.D. FEBS Lett. (1997) [Pubmed]
  24. Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPARalpha-mediated pathway. Armstrong, M.B., Towle, H.C. Am. J. Physiol. Endocrinol. Metab. (2001) [Pubmed]
  25. AhR and PPARalpha: antagonistic effects on CYP2B and CYP3A, and additive inhibitory effects on CYP2C11. Shaban, Z., Soliman, M., El-Shazly, S., El-Bohi, K., Abdelazeez, A., Kehelo, K., Kim, H.S., Muzandu, K., Ishizuka, M., Kazusaka, A., Fujita, S. Xenobiotica (2005) [Pubmed]
  26. p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response. Barger, P.M., Browning, A.C., Garner, A.N., Kelly, D.P. J. Biol. Chem. (2001) [Pubmed]
  27. Effect of PPAR-alpha and -gamma agonist on the expression of visfatin, adiponectin, and TNF-alpha in visceral fat of OLETF rats. Choi, K.C., Ryu, O.H., Lee, K.W., Kim, H.Y., Seo, J.A., Kim, S.G., Kim, N.H., Choi, D.S., Baik, S.H., Choi, K.M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  28. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Braissant, O., Foufelle, F., Scotto, C., Dauça, M., Wahli, W. Endocrinology (1996) [Pubmed]
  29. Peroxisome proliferator-activated receptor (PPAR) alpha-regulated growth responses and their importance to hepatocarcinogenesis. James, N.H., Gill, J.H., Brindle, R., Woodyatt, N.J., Macdonald, N., Rolfe, M., Hasmall, S.C., Tugwood, J.D., Holden, P.R., Roberts, R.A. Toxicol. Lett. (1998) [Pubmed]
  30. Effect of peroxisome proliferator-activated receptor activators on tumor necrosis factor-alpha expression in neonatal rat cardiac myocytes. Ye, P., Fang, H., Zhou, X., He, Y.L., Liu, Y.X. Chin. Med. Sci. J. (2004) [Pubmed]
  31. The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin. Shalev, A., Siegrist-Kaiser, C.A., Yen, P.M., Wahli, W., Burger, A.G., Chin, W.W., Meier, C.A. Endocrinology (1996) [Pubmed]
WikiGenes - Universities