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Gene Review

MTO1  -  mitochondrial tRNA translation optimization 1

Homo sapiens

Synonyms: CGI-02, COXPD10, Protein MTO1 homolog, mitochondrial
 
 
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High impact information on MTO1

  • Functional conservation of this protein is supported by the observation that isolated human MTO1 cDNA can complement the respiratory deficient phenotype of yeast mto1 cells carrying P(R)454 mutation [1].
  • MTO1 is ubiquitously expressed in various tissues, but with a markedly elevated expression in tissues of high metabolic rates including cochlea [1].
  • Two genes, MTO1 and GTPBP3, showed strongly suggestive linkage and significant LD results [2].
 

Biological context of MTO1

  • In yeast, the mutant alleles of MTO1, encoding a mitochondrial protein, manifest respiratory-deficient phenotype only when coupled with the mitochondrial 15 S rRNA P(R)454 mutation corresponding to human A1555G mutation [1].

References

 
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