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Gene Review

PVRL3  -  poliovirus receptor-related 3

Homo sapiens

Synonyms: CD113, CDW113, CDw113, DKFZP566B0846, NECTIN-3, ...
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Disease relevance of PVRL3


High impact information on PVRL3


Biological context of PVRL3


Anatomical context of PVRL3

  • Ca2+ -independent immunoglobulin-like cell-cell adhesion molecules, nectin-2 and nectin-3, asymmetrically localize at the Sertoli cell side and at the spermatid side of Sertoli-spermatid junctions, respectively [1].
  • Nectin-3(-/-) mice had defects in the later steps of sperm morphogenesis including distorted nuclei and abnormal distribution of mitochondria, as well as in localization of nectin-2 at the Sertoli-spermatid junctions [1].

Other interactions of PVRL3

  • We have isolated nectin3/PRR3, the fourth human member of the nectin/PRR family, also described as the alpha herpes virus receptor family [4].
  • These results suggest that the human nectin3/PRR3 is a new afadin-associated molecule [4].
  • One of them, named necl-5, which does not homophilically trans-interact, but heterophilically trans-interacts with nectin-3, regulates cell migration and adhesion [6].

Analytical, diagnostic and therapeutic context of PVRL3


  1. Role of cell adhesion molecule nectin-3 in spermatid development. Inagaki, M., Irie, K., Ishizaki, H., Tanaka-Okamoto, M., Miyoshi, J., Takai, Y. Genes Cells (2006) [Pubmed]
  2. Restoration of E-cadherin-based cell-cell adhesion by overexpression of nectin in HSC-39 cells, a human signet ring cell gastric cancer cell line. Peng, Y.F., Mandai, K., Nakanishi, H., Ikeda, W., Asada, M., Momose, Y., Shibamoto, S., Yanagihara, K., Shiozaki, H., Monden, M., Takeichi, M., Takai, Y. Oncogene (2002) [Pubmed]
  3. Expression of nectin-1, nectin-3, N-cadherin, and NCAM in spinal motoneurons after sciatic nerve transection. Zelano, J., Wallquist, W., Hailer, N.P., Cullheim, S. Exp. Neurol. (2006) [Pubmed]
  4. Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. Reymond, N., Borg, J.P., Lecocq, E., Adelaide, J., Campadelli-Fiume, G., Dubreuil, P., Lopez, M. Gene (2000) [Pubmed]
  5. Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin- and cadherin-based adherens junctions. Sato, T., Irie, K., Ooshio, T., Ikeda, W., Takai, Y. Genes Cells (2004) [Pubmed]
  6. Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization. Takai, Y., Irie, K., Shimizu, K., Sakisaka, T., Ikeda, W. Cancer Sci. (2003) [Pubmed]
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