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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SENP3  -  SUMO1/sentrin/SMT3 specific peptidase 3

Homo sapiens

Synonyms: DKFZP586K0919, DKFZp762A152, SMT3IP1, SSP3, SUMO-1-specific protease 3, ...
 
 
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High impact information on SENP3

  • Opposing the action of class IIa deacetylases, the SUMO protease SENP3 reverses the sumoylation to augment the transcriptional and myogenic activities of MEF2 [1].
  • We were also able to show that SENP3 has substrate specificity similar to that of SENP5 [2].

References

  1. Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. Grégoire, S., Yang, X.J. Mol. Cell. Biol. (2005) [Pubmed]
  2. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. Gong, L., Yeh, E.T. J. Biol. Chem. (2006) [Pubmed]
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