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Hsf4  -  heat shock transcription factor 4

Mus musculus

Synonyms: HSF 4, HSTF 4, HSTF4, Heat shock factor protein 4, Heat shock transcription factor 4, ...
 
 
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Disease relevance of Hsf4

  • Early transposable element insertion in intron 9 of the Hsf4 gene results in autosomal recessive cataracts in lop11 and ldis1 mice [1].
 

High impact information on Hsf4

  • In mammals, HSF1 is the main factor controlling the stress-inducible expression of Hsp genes while the functions of HSF2 and HSF4 are less clear [2].
  • Vertebrate cells express a family of heat shock transcription factors (HSF1 to HSF4) that coordinate the inducible regulation of heat shock genes in response to diverse signals [3].
  • Analysis of the mouse genome for the lop11 critical region identified Hsf4 as a candidate gene [1].
  • Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation [4].
 

Biological context of Hsf4

  • These data suggest that HSF4 acts as a critical transcription factor for lens-specific target gene expression, in particular regulating the small 25 kDa heat shock protein that acts as a modifier for lens opacity and cataract development [4].

References

  1. Early transposable element insertion in intron 9 of the Hsf4 gene results in autosomal recessive cataracts in lop11 and ldis1 mice. Talamas, E., Jackson, L., Koeberl, M., Jackson, T., McElwee, J.L., Hawes, N.L., Chang, B., Jablonski, M.M., Sidjanin, D.J. Genomics (2006) [Pubmed]
  2. Heat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice. McMillan, D.R., Christians, E., Forster, M., Xiao, X., Connell, P., Plumier, J.C., Zuo, X., Richardson, J., Morgan, S., Benjamin, I.J. Mol. Cell. Biol. (2002) [Pubmed]
  3. Stress-specific activation and repression of heat shock factors 1 and 2. Mathew, A., Mathur, S.K., Jolly, C., Fox, S.G., Kim, S., Morimoto, R.I. Mol. Cell. Biol. (2001) [Pubmed]
  4. Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation. Min, J.N., Zhang, Y., Moskophidis, D., Mivechi, N.F. Genesis (2004) [Pubmed]
 
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