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Gene Review

Ifi202b  -  interferon activated gene 202B

Mus musculus

Synonyms: Ifbip-1, Ifi-202, Ifi202, Ifi202a, Interferon-activable protein 202, ...
 
 
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Disease relevance of Ifi202b

 

High impact information on Ifi202b

 

Biological context of Ifi202b

  • The Ifi202 gene is part of the interferon-activatable murine gene 200 cluster on chromosome 1 [5].
  • Increased Expression of Ifi202, an IFN-Activatable Gene, in B6.Nba2 Lupus Susceptible Mice Inhibits p53-Mediated Apoptosis [2].
  • Together, our observations support the idea that the transcriptional activation of Ifi202 gene by Rb/JunD may be important for the regulation of cell growth and survival [6].
  • We have now raised a polyclonal antiserum against the 202 protein that is encoded by the Ifi 202 gene from the same gene cluster and regions of which are homologous to those from the 204 protein [7].
  • Generation of mice congenic for the Nba2 locus on the C57BL/6 genetic background, coupled with gene expression profiling, recently identified the interferon-activatable Ifi202 gene (encodes the protein p202) as a candidate lupus-susceptibility gene [8].
 

Regulatory relationships of Ifi202b

  • Here, we report that Rb upregulates expression of Ifi202 gene [6].
 

Other interactions of Ifi202b

  • Characteristics of three homologous 202 genes (Ifi202a, Ifi202b, and Ifi202c) from the murine interferon-activatable gene 200 cluster [5].
  • The interferon-activated genes Ifi202, Ifi203, and Ifi204 were linked within 75-150 kb [9].
 

Analytical, diagnostic and therapeutic context of Ifi202b

References

  1. Interleukin-6 induces expression of Ifi202, an interferon-inducible candidate gene for lupus susceptibility. Pramanik, R., Jørgensen, T.N., Xin, H., Kotzin, B.L., Choubey, D. J. Biol. Chem. (2004) [Pubmed]
  2. Increased Expression of Ifi202, an IFN-Activatable Gene, in B6.Nba2 Lupus Susceptible Mice Inhibits p53-Mediated Apoptosis. Xin, H., D'Souza, S., Jørgensen, T.N., Vaughan, A.T., Lengyel, P., Kotzin, B.L., Choubey, D. J. Immunol. (2006) [Pubmed]
  3. Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus. Rozzo, S.J., Allard, J.D., Choubey, D., Vyse, T.J., Izui, S., Peltz, G., Kotzin, B.L. Immunity (2001) [Pubmed]
  4. Interferon-alpha-inducible proteins are novel autoantigens in murine lupus. Hueber, W., Zeng, D., Strober, S., Utz, P.J. Arthritis Rheum. (2004) [Pubmed]
  5. Characteristics of three homologous 202 genes (Ifi202a, Ifi202b, and Ifi202c) from the murine interferon-activatable gene 200 cluster. Wang, H., Chatterjee, G., Meyer, J.J., Liu, C.J., Manjunath, N.A., Bray-Ward, P., Lengyel, P. Genomics (1999) [Pubmed]
  6. Retinoblastoma (Rb) protein upregulates expression of the Ifi202 gene encoding an interferon-inducible negative regulator of cell growth. Xin, H., Pramanik, R., Choubey, D. Oncogene (2003) [Pubmed]
  7. Interferon action: cytoplasmic and nuclear localization of the interferon-inducible 52-kD protein that is encoded by the Ifi 200 gene from the gene 200 cluster. Choubey, D., Lengyel, P. J. Interferon Res. (1993) [Pubmed]
  8. Interferon-inducible p202 in the susceptibility to systemic lupus. Choubey, D., Kotzin, B.L. Front. Biosci. (2002) [Pubmed]
  9. Physical mapping of a family of interferon-activated genes, serum amyloid P-component, and alpha-spectrin on mouse chromosome 1. Kingsmore, S.F., Snoddy, J., Choubey, D., Lengyel, P., Seldin, M.F. Immunogenetics (1989) [Pubmed]
  10. An update on genetic studies of systemic lupus erythematosus. Tsao, B.P. Current rheumatology reports. (2002) [Pubmed]
 
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