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Plod2  -  procollagen lysine, 2-oxoglutarate 5...

Mus musculus

Synonyms: D530025C14Rik, LH2, Lysyl hydroxylase 2, Plod-2, Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2, ...
 
 
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High impact information on Plod2

  • Expression of LH-2 was found in B- and T-lymphoid cell lines [1].
  • A screen for early markers of B-lymphocyte differentiation has identified a homeobox gene, denoted LH-2, that has a pattern of expression distinct from that of other related genes [1].
  • In embryonic and adult tissues, the highest level of LH-2 expression was found in discrete regions of the developing central nervous system, primarily in diencephalic and telencephalic structures, and in a subset of lymphoid tissues [1].
  • The expression pattern and structural characteristics of the LH-2 gene suggest that it encodes a transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types [1].
  • The LH-2 cDNA sequence encodes a polypeptide of 426 amino acids that contains a homeodomain and two repeats of a cysteine-rich domain referred to as a LIM domain [1].
 

Biological context of Plod2

 

Anatomical context of Plod2

  • MATERIALS AND METHODS: To directly test this hypothesis, several MC3T3-E1 cell-derived clones expressing higher (sense [S]) or lower (antisense [AS]) levels of LH2b, the predominant form of LH2 in this cell line, were established and cultured for 2 weeks, and collagen cross-links and precursor aldehydes in the matrices were analyzed [3].
 

Associations of Plod2 with chemical compounds

  • Recently, we proposed that LH2 might modulate collagen cross-linking pattern through its action on Lys residues located in the telopeptide domains of collagen [3].
 

Other interactions of Plod2

References

  1. LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Xu, Y., Baldassare, M., Fisher, P., Rathbun, G., Oltz, E.M., Yancopoulos, G.D., Jessell, T.M., Alt, F.W. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. The lysyl hydroxylase isoforms are widely expressed during mouse embryogenesis, but obtain tissue- and cell-specific patterns in the adult. Salo, A.M., Sipil??, L., Sormunen, R., Ruotsalainen, H., Vainio, S., Myllyl??, R. Matrix Biol. (2006) [Pubmed]
  3. Lysyl hydroxylase-2b directs collagen cross-linking pathways in MC3T3-E1 cells. Pornprasertsuk, S., Duarte, W.R., Mochida, Y., Yamauchi, M. J. Bone Miner. Res. (2004) [Pubmed]
  4. Differential gene expression of collagen-binding small leucine-rich proteoglycans and lysyl hydroxylases, during mineralization by MC3T3-E1 cells cultured on titanium implant material. Takashi, M., Tsubaki, S., Tsuzuki, T., Duarte, W.R., Yamauchi, M., Sato, H. Eur. J. Oral Sci. (2005) [Pubmed]
 
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