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Gene Review: 

BLOC1S1  -  biogenesis of lysosomal organelles complex...

Homo sapiens

Synonyms: BLOC-1 subunit 1, BLOS1, Biogenesis of lysosome-related organelles complex 1 subunit 1, GCN5-like protein 1, GCN5L1, ...
 
 
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Disease relevance of BLOC1S1

 

Psychiatry related information on BLOC1S1

  • Blos (1985) suggested that individuation perhaps necessarily includes the confirmation of the child's adult status by the same-sex parent, called "the blessing." Of the 281 late adolescents in the present study, 71.5% indicated they had received some type of blessing from a parent and described the event as meaningful [2].
  • Peter Blos' modern psychoanalytic interpretation of adolescence [3].
  • Depression during adolescence has been associated with a number of factors, including failure to individuate (Blos, 1968), insecure attachments (Armsden, McCauley, Greenberg, Burke, & Mitchell, 1990), negative parental representations, and object relations that lack self-other differentiation (Blatt, Wein, Chevron, & Quinlan, 1979) [4].
  • Both Blos' (1974) ideas on the negative Oedipus complex and Kohut's (1966) ideas on the developmental line of narcissism prove to be useful ways of linking the clinical picture of paranoia to the psychic structure of the ego-ideal [5].
 

High impact information on BLOC1S1

  • Gcn5-like HATs utilize an ordered sequential mechanism involving direct nucleophilic attack of the N-epsilon-lysine on the enzyme-bound acetyl-CoA [6].
  • Instead, fibroblasts under the basal layer of the outer scale surface (BLOS) made numerous contacts with the basement membrane, suggesting that more dermal-epidermal interactions take place on this side of the scale [7].
  • This cDNA, termed GCN5L1 (GCN5-like 1), consists of 545 nucleotides including an open reading frame of 378 bp that encodes a 126-amino-acid peptide having 23.5% identity to yeast GCN5 [8].
  • Double-blind, placebo-controlled, randomized trial of prophylactic metoprolol for reduction of hospital length of stay after heart surgery: the beta-Blocker Length Of Stay (BLOS) study [9].
 

Analytical, diagnostic and therapeutic context of BLOC1S1

  • Molecular cloning of a novel human cDNA, RT14, containing a putative ORF highly conserved between human, fruit fly, and nematode [10].

References

  1. Metoprolol prophylaxis against postoperative atrial fibrillation increases length of hospital stay in patients not on pre-operative beta blockers: the beta blocker length of stay (BLOS) trial. Crystal, E., Thorpe, K.E., Connolly, S.J., Lamy, A., Cybulsky, I., Carroll, S., Roberts, R., Gent, M. Heart (2004) [Pubmed]
  2. The blessing as a rite of passage in adolescence. Bjornsen, C.A. Adolescence. (2000) [Pubmed]
  3. Peter Blos' modern psychoanalytic interpretation of adolescence. Muuss, R.E. Journal of adolescence. (1980) [Pubmed]
  4. Predictors of depression in female adolescents. Milne, L.C., Lancaster, S. Adolescence. (2001) [Pubmed]
  5. Paranoia and the ego-ideal: death of a salesman's son. Garfield, D.A. The Journal of the American Academy of Psychoanalysis. (1988) [Pubmed]
  6. Catalytic mechanism of a MYST family histone acetyltransferase. Berndsen, C.E., Albaugh, B.N., Tan, S., Denu, J.M. Biochemistry (2007) [Pubmed]
  7. Differentiation of the epidermis during scale formation in embryos of lizard. Alibardi, L. J. Anat. (1998) [Pubmed]
  8. Isolation and characterization of a human cDNA clone (GCN5L1) homologous to GCN5, a yeast transcription activator. Inoue, M., Isomura, M., Ikegawa, S., Fujiwara, T., Shin, S., Moriya, H., Nakamura, Y. Cytogenet. Cell Genet. (1996) [Pubmed]
  9. Double-blind, placebo-controlled, randomized trial of prophylactic metoprolol for reduction of hospital length of stay after heart surgery: the beta-Blocker Length Of Stay (BLOS) study. Connolly, S.J., Cybulsky, I., Lamy, A., Roberts, R.S., O'brien, B., Carroll, S., Crystal, E., Thorpe, K.E., Gent, M. Am. Heart J. (2003) [Pubmed]
  10. Molecular cloning of a novel human cDNA, RT14, containing a putative ORF highly conserved between human, fruit fly, and nematode. Watanabe, T.K., Fujiwara, T., Shinomiya, H., Kuga, Y., Hishigaki, H., Nakamura, Y., Hirai, Y. DNA Res. (1995) [Pubmed]
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