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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

irp6B  -  membrane protein permease Irp6B

Corynebacterium diphtheriae NCTC 13129

 
 
 
 
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High impact information on irp6B

  • The irp6A allele in HC1 and the irp6B allele in HC5 encoded single amino acid substitutions in their predicted protein products, and the irp6C allele in HC4 caused premature chain termination of its predicted protein product [1].
  • Complementation by subclones of pCM6ABC demonstrated that mutant alleles of irp6A, irp6C, and irp6B were responsible for the phenotypes of HC1, HC4, and HC5, respectively [1].
  • Strain HC3 was found to have a chain-terminating mutation in dtxR in addition to a missense mutation in its irp6B allele [1].

References

  1. Identification of a DtxR-regulated operon that is essential for siderophore-dependent iron uptake in Corynebacterium diphtheriae. Qian, Y., Lee, J.H., Holmes, R.K. J. Bacteriol. (2002) [Pubmed]
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