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Gene Review:

angR - ORF7

Vibrio anguillarum 775

Wertheimer, A.M. et al., Farrell, D.H. et al., Balado, M. et al., Stork, M. et al., Salinas, P.C. et al., et al.

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Disease relevance of angR

The angR locus in Vibrio anguillarum encodes a trans-acting transcriptional activator which modulates several Fe2(+)-regulated loci in the anguibactin biosynthesis gene cluster [1].
A region upstream from the angR gene is shown to have similarity with Fe2(+)-regulated operators in Escherichia coli which bind the Fur protein [1].

High impact information on angR

We also show in this study that the angT gene, found downstream of angR, intervenes in the mechanism of anguibactin production but is not essential for virulence or iron transport gene expression [2].
Characterization of the angR gene of Vibrio anguillarum: essential role in virulence [2].
In order to dissect the specific domains of AngR associated with regulation of iron transport gene expression, anguibactin production, and virulence, we also generated a panel of site-directed angR mutants, as well as deletion derivatives [2].
The authors have identified the genes involved in 2,3-dihydroxybenzoic acid (DHBA) biosynthesis (vabA, vabB and vabC) and activation (vabE), and a gene (vabF) encoding a non-ribosomal peptide synthetase, which is putatively involved in the assembly of the siderophore components [3].

Biological context of angR

Therefore, study of the expression of the angR gene and the properties of its product, the AngR protein, may contribute to the understanding of the mechanisms of virulence of this pathogen [2].
These transport genes, together with the biosynthesis genes angR and angT, are included in the iron transport biosynthesis operon (ITBO) [4].

Associations of angR with chemical compounds

The angR gene was found to be responsible for this difference in levels of anguibactin produced [5].

Analytical, diagnostic and therapeutic context of angR

Northern blot analysis showed that angR encodes a 3.1-kb transcript which is expressed only under iron-limiting conditions [6].

References

A regulatory gene, angR, of the iron uptake system of Vibrio anguillarum: similarity with phage P22 cro and regulation by iron. Farrell, D.H., Mikesell, P., Actis, L.A., Crosa, J.H. Gene (1990) [Pubmed]
Characterization of the angR gene of Vibrio anguillarum: essential role in virulence. Wertheimer, A.M., Verweij, W., Chen, Q., Crosa, L.M., Nagasawa, M., Tolmasky, M.E., Actis, L.A., Crosa, J.H. Infect. Immun. (1999) [Pubmed]
A gene cluster involved in the biosynthesis of vanchrobactin, a chromosome-encoded siderophore produced by Vibrio anguillarum. Balado, M., Osorio, C.R., Lemos, M.L. Microbiology (Reading, Engl.) (2006) [Pubmed]
Plasmid-mediated iron uptake and virulence in Vibrio anguillarum. Stork, M., Di Lorenzo, M., Welch, T.J., Crosa, L.M., Crosa, J.H. Plasmid (2002) [Pubmed]
A single amino acid change in AngR, a protein encoded by pJM1-like virulence plasmids, results in hyperproduction of anguibactin. Tolmasky, M.E., Actis, L.A., Crosa, J.H. Infect. Immun. (1993) [Pubmed]
Regulation of angR, a gene with regulatory and biosynthetic functions in the pJM1 plasmid-mediated iron uptake system of Vibrio anguillarum. Salinas, P.C., Crosa, J.H. Gene (1995) [Pubmed]

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