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Gene Review:

fatA - ORF6; outer membrane receptor

Vibrio anguillarum 775

Waldbeser, L.S. et al., Chen, Q. et al., Chen, Q. et al.

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Disease relevance of fatA

Mechanisms for negative regulation by iron of the fatA outer membrane protein gene expression in Vibrio anguillarum 775 [1].
In addition, we found that fatA mRNA expression is slightly reduced in the presence of Escherichia coli Fur [1].

High impact information on fatA

The negative regulation of the expression of iron transport genes fatA and fatB in Vibrio anguillarum is mediated by a chromosome-encoded Fur protein and a plasmid pJM1-derived antisense RNA (RNAalpha), which is preferentially expressed under iron-rich conditions [2].
In addition, we present evidence that anguibactin itself enhanced transcription of the iron-transport genes fatA and fatB, independently of AngR and the trans-acting factor (TAF) product(s) [3].

Analytical, diagnostic and therapeutic context of fatA

This RNA is only expressed under iron-rich conditions and acts as a negative regulator of FatA synthesis, with slight but discernible decrease in the steady-state level of fatA mRNA determined by RNase protection and by Northern blot analysis [1].

References

Mechanisms for negative regulation by iron of the fatA outer membrane protein gene expression in Vibrio anguillarum 775. Waldbeser, L.S., Tolmasky, M.E., Actis, L.A., Crosa, J.H. J. Biol. Chem. (1993) [Pubmed]
Antisense RNA, fur, iron, and the regulation of iron transport genes in Vibrio anguillarum. Chen, Q., Crosa, J.H. J. Biol. Chem. (1996) [Pubmed]
The AngR protein and the siderophore anguibactin positively regulate the expression of iron-transport genes in Vibrio anguillarum. Chen, Q., Wertheimer, A.M., Tolmasky, M.E., Crosa, J.H. Mol. Microbiol. (1996) [Pubmed]

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