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Gene Review:

LV031 - transposase

Klebsiella pneumoniae CG43

Kahn, K. et al., Lai, Y.C. et al., Queenan, A.M. et al.

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Disease relevance of LV031

The bla(FOX-5) coding region was located next to a transposase gene from the Aeromonas salmonicida insertion element ISAS2 [1].
A 230-residue domain near the amino terminus of the TnpA protein has 15.4% amino acid sequence identity with a corresponding domain for the putative transposase encoded by Lactococcus lactis insertion sequence S1 (ISS1) [2].
In addition, the sequence for the carboxyl-terminal 600 residues of the TnpA protein is 20.0% identical to that for the TniA transposase encoded by Tn5090 on Klebsiella aerogenes plasmid R751 [2].

High impact information on LV031

Two of the sequences were found to be the genes encoding the transposase of Tn3926 and a capsule polysaccharide exporting enzyme [3].

References

Cloning and biochemical characterization of FOX-5, an AmpC-type plasmid-encoded beta-lactamase from a New York City Klebsiella pneumoniae clinical isolate. Queenan, A.M., Jenkins, S., Bush, K. Antimicrob. Agents Chemother. (2001) [Pubmed]
Characterization of transposon Tn5469 from the cyanobacterium Fremyella diplosiphon. Kahn, K., Schaefer, M.R. J. Bacteriol. (1995) [Pubmed]
Identification of genes present specifically in a virulent strain of Klebsiella pneumoniae. Lai, Y.C., Yang, S.L., Peng, H.L., Chang, H.Y. Infect. Immun. (2000) [Pubmed]

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