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Gene Review

rpoA  -  DNA-directed RNA polymerase subunit alpha

Bordetella pertussis Tohama I

 
 
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Disease relevance of rpoA

  • Corroboration of this effect was obtained by overexpressing rpoA on a plasmid in wild-type B. pertussis, which caused the same phenotype as the mutants showed [1].
 

Analytical, diagnostic and therapeutic context of rpoA

  • Our hypothesis that these mutations cause an overexpression of rpoA was confirmed by Western immunoblotting and translational fusion analysis [1].

References

  1. Effect of mutations causing overexpression of RNA polymerase alpha subunit on regulation of virulence factors in Bordetella pertussis. Carbonetti, N.H., Fuchs, T.M., Patamawenu, A.A., Irish, T.J., Deppisch, H., Gross, R. J. Bacteriol. (1994) [Pubmed]
 
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