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Gene Review

bvgR  -  regulatory protein BvgR

Bordetella pertussis Tohama I

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Disease relevance of bvgR


High impact information on bvgR

  • By constructing a strain with a deletion in the bvgR regulatory locus, we also show that ectopic expression of Bvg- phase phenotypes decreases the efficiency of colonization, underscoring the importance of Bvg-mediated repression of gene expression in vivo [3].
  • Our analyses demonstrated that all four genes are repressed by the product of the bvgR locus and are activated by the product of the risA locus [4].
  • We undertook an analysis of the transcriptional activation of bvgR expression [5].
  • Analysis of bvgR expression in Bordetella pertussis [5].
  • We have undertaken deletion and complementation studies, as well as sequence analysis, in order to identify the bvgR open reading frame and identify the cis-acting sequences required for regulated expression of bvgR [1].

Analytical, diagnostic and therapeutic context of bvgR

  • We identified the bvgR transcript by Northern blot analysis and identified the start site of transcription by primer extension [5].


  1. Characterization of the bvgR locus of Bordetella pertussis. Merkel, T.J., Barros, C., Stibitz, S. J. Bacteriol. (1998) [Pubmed]
  2. Contribution of regulation by the bvg locus to respiratory infection of mice by Bordetella pertussis. Merkel, T.J., Stibitz, S., Keith, J.M., Leef, M., Shahin, R. Infect. Immun. (1998) [Pubmed]
  3. Neither the Bvg- phase nor the vrg6 locus of Bordetella pertussis is required for respiratory infection in mice. Martinez de Tejada, G., Cotter, P.A., Heininger, U., Camilli, A., Akerley, B.J., Mekalanos, J.J., Miller, J.F. Infect. Immun. (1998) [Pubmed]
  4. Activation of the vrg6 promoter of Bordetella pertussis by RisA. Cróinín, T.O., Grippe, V.K., Merkel, T.J. J. Bacteriol. (2005) [Pubmed]
  5. Analysis of bvgR expression in Bordetella pertussis. Merkel, T.J., Boucher, P.E., Stibitz, S., Grippe, V.K. J. Bacteriol. (2003) [Pubmed]
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