Disease relevance of bvgR

• Characterization of the bvgR locus of Bordetella pertussis [1].
• Our results indicate that the bvgR-mediated regulation of gene expression contributes to respiratory infection of mice [2].

High impact information on bvgR

• By constructing a strain with a deletion in the bvgR regulatory locus, we also show that ectopic expression of Bvg- phase phenotypes decreases the efficiency of colonization, underscoring the importance of Bvg-mediated repression of gene expression in vivo [3].
• Our analyses demonstrated that all four genes are repressed by the product of the bvgR locus and are activated by the product of the risA locus [4].
• We undertook an analysis of the transcriptional activation of bvgR expression [5].
• Analysis of bvgR expression in Bordetella pertussis [5].
• We have undertaken deletion and complementation studies, as well as sequence analysis, in order to identify the bvgR open reading frame and identify the cis-acting sequences required for regulated expression of bvgR [1].

Analytical, diagnostic and therapeutic context of bvgR

• We identified the bvgR transcript by Northern blot analysis and identified the start site of transcription by primer extension [5].

References