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Gene Review

Serpinb10  -  serpin peptidase inhibitor, clade B...

Rattus norvegicus

Synonyms: Serpin B10, TGF-beta-repressible serine proteinase inhibitor, Transforming growth factor beta repressible serpin, Trespin
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High impact information on Serpinb10


Biological context of Serpinb10


Anatomical context of Serpinb10

  • Together these data strongly suggest that Trespin has critical functions tied to the regulation of growth, differentiation, and apoptosis of prostatic epithelial cells [2].
  • In this report Trespin expression was studied in prostatic cell lines, NRP-152, NRP-154, and DP-153, derived from the Lobund-Wistar rat [2].

Associations of Serpinb10 with chemical compounds

  • We recently identified a novel rat ov-serpin, Trespin, which inhibits the trypsin-like serine proteinase plasmin and is expressed in several tissues, including prostate [2].


  1. Identification and characterization of a novel rat ov-serpin family member, trespin. Chipuk, J.E., Stewart, L.V., Ranieri, A., Song, K., Danielpour, D. J. Biol. Chem. (2002) [Pubmed]
  2. Regulation of trespin expression by modulators of cell growth, differentiation, and apoptosis in prostatic epithelial cells. Stewart, L.V., Song, K., Hsing, A.Y., Danielpour, D. Exp. Cell Res. (2003) [Pubmed]
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