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Gene Review

Nptx1  -  neuronal pentraxin I

Rattus norvegicus

Synonyms: 47 kDa taipoxin-binding protein, NP-I, NP1, Neuronal pentraxin I, Neuronal pentraxin-1
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Disease relevance of Nptx1

  • In primary cortical neurons, NP1 protein was induced >2.5-fold (p < 0.001) after their exposure to hypoxia that caused approximately 30-40% neuronal death [1].
  • Pregnancy increased (p < 0.01) food intake, body weight, weight gain, and food efficiency ratio (P2 vs NP2 and P1 vs NP1, respectively), but the treatment of oil included in the diets did not alter these parameters [2].

High impact information on Nptx1


Biological context of Nptx1

  • Time-course studies indicated that overexpression of NP1 protein reaches a maximum after 4 h of exposure to potassium deprivation and 4 h before significant cell death [4].
  • Our hypothesis is that an incomplete DNA hydrolysis to nucleosides by the conventional nuclease P1 (NP1) and alkaline phosphatase (AP) digestion system plays an important role in contributing to the variability of measurements using HPLC coupled with UV and electrochemical (EC) detection [5].
  • Inhibiting the phosphorylation of the p38 mitogen-activated protein kinase without modifying JNK, neither diminishes cell death nor inhibits NP1 overexpression in nondepolarizing conditions [6].
  • This novel protein, NPCD (Neuronal Pentraxin with Chromo Domain), has multiple cytoplasmic isoforms generated by alternative splicing that are selectively expressed in neurons [7].
  • These cytoplasmic NPCD isoforms are composed of a neuronal pentraxin domain (formerly thought exclusively extracellular) linked to a chromo domain (formerly thought exclusively nuclear); this protein motif organization is unprecedented [7].

Anatomical context of Nptx1

  • Immunofluorescence analyses revealed elevated neuronal expression of NP1 in the ipsilateral cerebral cortex from 6 hr to 7 d and in the hippocampal CA1 and CA3 regions from 24 hr to 7 d after HI [1].
  • RT-PCR, western and immunocytochemical analyses revealed that oligodendrocytes expressed NP1, several alternatively spliced isoforms of NP2, and a broad spectrum of both soluble (Class 3), membrane-spanning (Class 4-6), and membrane-tethered (Class 7) semaphorin ligands [8].

Associations of Nptx1 with chemical compounds

  • Our results show that NP1 induction mediates hypoxic-ischemic injury probably by interacting with and modulating GluR1 and potentially other excitatory glutamate receptors [1].
  • Subsequently, DNA was analysed by nuclease P1 (NP1) or butanol-enriched 32P-postlabeling [9].
  • DNA obtained from the liver of rats fed IQ was 32P-labeled by the standard method and the 32P-labeled nucleotides obtained were incubated with PNK and NP1 to remove 3'-phosphate groups and then digested with PDEI [10].

Other interactions of Nptx1


Analytical, diagnostic and therapeutic context of Nptx1

  • Reverse-Northern and Northern blot analyses confirmed that treatment with low potassium induces overexpression of NP1 mRNA, with a subsequent increase in NP1 protein levels [4].


  1. Neuronal pentraxin 1: a novel mediator of hypoxic-ischemic injury in neonatal brain. Hossain, M.A., Russell, J.C., O'Brien, R., Laterra, J. J. Neurosci. (2004) [Pubmed]
  2. Lipaemia and liver composition in pregnant rats consuming olive oil and olive oil used for frying. López-Varela, S., Sánchez-Muniz, F.J. Zeitschrift für Ernährungswissenschaft. (1997) [Pubmed]
  3. Neuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system. Schlimgen, A.K., Helms, J.A., Vogel, H., Perin, M.S. Neuron (1995) [Pubmed]
  4. Overexpression of neuronal pentraxin 1 is involved in neuronal death evoked by low K(+) in cerebellar granule cells. DeGregorio-Rocasolano, N., Gasull, T., Trullas, R. J. Biol. Chem. (2001) [Pubmed]
  5. Importance of complete DNA digestion in minimizing variability of 8-oxo-dG analyses. Huang, X., Powell, J., Mooney, L.A., Li, C., Frenkel, K. Free Radic. Biol. Med. (2001) [Pubmed]
  6. Glycogen synthase kinase 3 activity mediates neuronal pentraxin 1 expression and cell death induced by potassium deprivation in cerebellar granule cells. Enguita, M., DeGregorio-Rocasolano, N., Abad, A., Trullas, R. Mol. Pharmacol. (2005) [Pubmed]
  7. Neuronal pentraxin with chromo domain (NPCD) is a novel class of protein expressed in multiple neuronal domains. Chen, B., Bixby, J.L. J. Comp. Neurol. (2005) [Pubmed]
  8. A role for semaphorins and neuropilins in oligodendrocyte guidance. Cohen, R.I., Rottkamp, D.M., Maric, D., Barker, J.L., Hudson, L.D. J. Neurochem. (2003) [Pubmed]
  9. Influences of DNA isolation and RNA contamination on carcinogen-DNA adduct analysis by 32P-postlabeling. Godschalk, R.W., Maas, L.M., Kleinjans, J.C., Van Schooten, F.J. Environ. Mol. Mutagen. (1998) [Pubmed]
  10. A new modification of the 32P-post-labeling method to recover IQ-DNA adducts as mononucleotides. Ochiai, M., Nakagama, H., Turesky, R.J., Sugimura, T., Nagao, M. Mutagenesis (1999) [Pubmed]
  11. Selective expression of Narp, a secreted neuronal pentraxin, in orexin neurons. Reti, I.M., Reddy, R., Worley, P.F., Baraban, J.M. J. Neurochem. (2002) [Pubmed]
  12. Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. Dodds, D.C., Omeis, I.A., Cushman, S.J., Helms, J.A., Perin, M.S. J. Biol. Chem. (1997) [Pubmed]
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