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OPLAH  -  5-oxoprolinase (ATP-hydrolysing)

Homo sapiens

Synonyms: 5-OPase, 5-Opase, 5-oxo-L-prolinase, 5-oxoprolinase, OPLA, ...
 
 
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Disease relevance of OPLAH

 

High impact information on OPLAH

 

Biological context of OPLAH

 

Anatomical context of OPLAH

  • Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery [9].
  • Using this assay method, we purified 5-OPase from bovine kidney cytosol until homogeneous results were obtained in sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) [9].
  • We hypothesized that RS-7897-derived OTCA was converted into L-Cys by 5-OPase and supplied sulfhydryl groups in vascular smooth muscle cells, the targets of the nitrate [9].
  • This study examined the effect of two commercially available, three-dimensional scaffolds, ultraporous beta-tricalcium phosphate ceramics (beta-TCP, Vitoss) and open-celled poly(lactic acid) foams (OPLA, Drilac), on the osteogenic differentiation potential of human dermal fibroblasts [11].
  • Dermal fibroblasts cultured on beta-TCP scaffolds in chemically-defined medium with vitamin D3 exhibited up-regulated gene and protein expression compared to cells cultured on OPLA scaffolds [11].
 

Associations of OPLAH with chemical compounds

 

Analytical, diagnostic and therapeutic context of OPLAH

References

  1. Transient 5-oxoprolinuria (pyroglutamic aciduria) with systemic acidosis in an adult receiving antibiotic therapy. Croal, B.L., Glen, A.C., Kelly, C.J., Logan, R.W. Clin. Chem. (1998) [Pubmed]
  2. Purification and characterization of a novel 5-oxoprolinase (without ATP-hydrolyzing activity) from Alcaligenes faecalis N-38A. Nishimura, A., Ozaki, Y., Oyama, H., Shin, T., Murao, S. Appl. Environ. Microbiol. (1999) [Pubmed]
  3. Sensitization effect of L-2-oxothiazolidine-4-carboxylate on tumor cells to melphalan and the role of 5-oxo-L-prolinase in glutathione modulation in tumor cells. Chen, X., Batist, G. Biochem. Pharmacol. (1998) [Pubmed]
  4. 5-Oxoprolinase deficiency associated with severe psychomotor developmental delay, failure to thrive, microcephaly and microcytic anaemia. Mayatepek, E., Hoffmann, G.F., Larsson, A., Becker, K., Bremer, H.J. J. Inherit. Metab. Dis. (1995) [Pubmed]
  5. Patients with genetic defects in the gamma-glutamyl cycle. Ristoff, E., Larsson, A. Chem. Biol. Interact. (1998) [Pubmed]
  6. Selective inhibition of gamma-glutamyl-cycle enzymes by substrate analogs. Griffith, O.W., Meister, A. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  7. Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: a potential new target for biochemical modulation of glutathione. Chen, X., Schecter, R.L., Griffith, O.W., Hayward, M.A., Alpert, L.C., Batist, G. Clin. Cancer Res. (1998) [Pubmed]
  8. L-2-[(13)C]oxothiazolidine-4-carboxylic acid: a probe for precursor mobilization for glutathione synthesis. Fukagawa, N.K., Hercules, E., Ajami, A.M. Am. J. Physiol. Endocrinol. Metab. (2000) [Pubmed]
  9. Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery. Watanabe, T., Abe, K., Ishikawa, H., Iijima, Y. Biol. Pharm. Bull. (2004) [Pubmed]
  10. Growth failure, encephalopathy, and endocrine dysfunctions in two siblings, one with 5-oxoprolinase deficiency. Cohen, L.H., Vamos, E., Heinrichs, C., Toppet, M., Courtens, W., Kumps, A., Mardens, Y., Carlsson, B., Grillner, L., Larsson, A. Eur. J. Pediatr. (1997) [Pubmed]
  11. Influence of three-dimensional scaffold on the expression of osteogenic differentiation markers by human dermal fibroblasts. Hee, C.K., Jonikas, M.A., Nicoll, S.B. Biomaterials (2006) [Pubmed]
  12. Purification and characterization of 5-oxo-L-prolinase from Paecilomyces varioti F-1, an ATP-dependent hydrolase active with L-2-oxothiazolidine-4-carboxylic acid. Mochizuki, K. Arch. Microbiol. (1999) [Pubmed]
  13. Evaluation of rhBMP-2 with an OPLA carrier in a canine posterolateral (transverse process) spinal fusion model. Sandhu, H.S., Kanim, L.E., Kabo, J.M., Toth, J.M., Zeegan, E.N., Liu, D., Seeger, L.L., Dawson, E.G. Spine. (1995) [Pubmed]
 
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