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Sytl1  -  synaptotagmin-like 1

Mus musculus

Synonyms: 9030417L18, Exophilin-7, PSGL-1, Slp1, Synaptotagmin-like protein 1
 
 
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Disease relevance of Sytl1

 

High impact information on Sytl1

  • Slp2-a is the most abundantly expressed of the Slp- and Slac2-family proteins in melanocytes and colocalizes with Rab27A on melanosomes [3].
  • Role of PSGL-1 binding to selectins in leukocyte recruitment [4].
  • Perspectives series: cell adhesion in vascular biology. Role of PSGL-1 binding to selectins in leukocyte recruitment [5].
  • Macrophages from PSGL-1-deficient mice recapitulated pharmacological inhibitor studies [6].
  • Synaptotagmin-like immunoreactivity (-LI) was localized to granules within the cytoplasm of a few endocrine cells located in the periphery of the islets, identified as somatostatin-containing cells, and in many nerve fibers within the islets [7].
 

Anatomical context of Sytl1

  • Here we report that it is also expressed in a developmentally regulated fashion in human and rat central nervous systems and that its protein carrier is P-selectin glycoprotein ligand-1 (PSGL-1), a ligand for selectins [2].
  • Moreover, P-/E-selectins was found on mouse ischemic endothelium and P-selectin glycoprotein ligand-1 (PSGL-1) on CB-derived EPCs [8].
  • Synaptotagmin-like protein (Slp) 2-a is a putative Rab27A/B-effector protein and is implicated in intracellular membrane transport [9].
  • In vivo we found that mice neutrophils were resistant to the cleavage of PSGL-1 by triflamp [10].
 

Associations of Sytl1 with chemical compounds

  • Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins [11].
  • Inhibitory effects of human alpha2-macroglobulin and mouse serum on the PSGL-1 and glycoprotein Ib proteolysis by a snake venom metalloproteinase, triflamp [10].
 

Physical interactions of Sytl1

  • Slac2-c/MyRIP is a specific Rab27A-binding protein that contains an N-terminal synaptotagmin-like protein (Slp) homology domain (SHD, a newly identified GTP-Rab27A-binding motif), but in contrast to the Slp family proteins, it lacks C-terminal tandem C2 domains [12].
 

Other interactions of Sytl1

 

Analytical, diagnostic and therapeutic context of Sytl1

  • Enrichment of MUC-1, PSGL-1 and GSLs, together with these signal transducer molecules in low-density membrane fraction was observable when fraction was prepared from cells either in nonionic detergent Brij 58 or in hypertonic alkaline conditions (500 mM Na(2)CO(3)) [14].

References

  1. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. Kuroda, T.S., Fukuda, M., Ariga, H., Mikoshiba, K. J. Biol. Chem. (2002) [Pubmed]
  2. The PEN5 epitope identifies an oligodendrocyte precursor cell population and pilocytic astrocytomas. Figarella-Branger, D., Daniel, L., André, P., Guia, S., Renaud, W., Monti, G., Vivier, E., Rougon, G. Am. J. Pathol. (1999) [Pubmed]
  3. Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes. Kuroda, T.S., Fukuda, M. Nat. Cell Biol. (2004) [Pubmed]
  4. Role of PSGL-1 binding to selectins in leukocyte recruitment. McEver, R.P., Cummings, R.D. J. Clin. Invest. (1997) [Pubmed]
  5. Perspectives series: cell adhesion in vascular biology. Role of PSGL-1 binding to selectins in leukocyte recruitment. McEver, R.P., Cummings, R.D. J. Clin. Invest. (1997) [Pubmed]
  6. PSGL-1 and mTOR regulate translation of ROCK-1 and physiological functions of macrophages. Fox, R., Nhan, T.Q., Law, G.L., Morris, D.R., Liles, W.C., Schwartz, S.M. EMBO J. (2007) [Pubmed]
  7. Identification of synaptic proteins and their isoform mRNAs in compartments of pancreatic endocrine cells. Jacobsson, G., Bean, A.J., Scheller, R.H., Juntti-Berggren, L., Deeney, J.T., Berggren, P.O., Meister, B. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  8. Enhancement of neovascularization with cord blood CD133+ cell-derived endothelial progenitor cell transplantation. Yang, C., Zhang, Z.H., Li, Z.J., Yang, R.C., Qian, G.Q., Han, Z.C. Thromb. Haemost. (2004) [Pubmed]
  9. Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells. Saegusa, C., Tanaka, T., Tani, S., Itohara, S., Mikoshiba, K., Fukuda, M. Genes Cells (2006) [Pubmed]
  10. Inhibitory effects of human alpha2-macroglobulin and mouse serum on the PSGL-1 and glycoprotein Ib proteolysis by a snake venom metalloproteinase, triflamp. Tseng, Y.L., Wu, W.B., Hsu, C.C., Peng, H.C., Huang, T.F. Toxicon (2004) [Pubmed]
  11. Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins. Fukuda, M., Mikoshiba, K. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  12. Identification and biochemical analysis of Slac2-c/MyRIP as a Rab27A-, myosin Va/VIIa-, and actin-binding protein. Kuroda, T.S., Fukuda, M. Meth. Enzymol. (2005) [Pubmed]
  13. Slac2-a/melanophilin contains multiple PEST-like sequences that are highly sensitive to proteolysis. Fukuda, M., Itoh, T. J. Biol. Chem. (2004) [Pubmed]
  14. Association of MUC-1 and SPGL-1 with low-density microdomain in T-lymphocytes: a preliminary note. Handa, K., Jacobs, F., Longenecker, B.M., Hakomori, S.I. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
 
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