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Cadps  -  Ca++-dependent secretion activator

Rattus norvegicus

Synonyms: CAPS-1, Calcium-dependent activator protein for secretion 1, Calcium-dependent secretion activator 1, Caps, Caps1, ...
 
 
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Disease relevance of Cadps

  • All these results revealed the therapeutic potential of Caps HT2 against vascular intimal damage and atherogenesis leading to various types of cardiovascular problems [1].
  • We found that in isolated hearts perfused with K(2)RBC before ischemia, O/I values were significantly increased (+68%, P < 0.01) and Caps values were significantly decreased (-25%, P < 0.05) after 25 min of reperfusion [2].
 

High impact information on Cadps

  • Moreover, in situ TUNEL reaction and agarose gel electrophoresis indicate that neonatal Caps treatment induces apoptosis of thymus cells [3].
  • The direct and indirect interaction between the nervous system and its transmitters with the immune system was evaluated in the rat by using the neurotoxin capsaicin (Caps) [3].
  • Analysis of TCR phenotype indicates that CD5(+) TCR gamma/delta(+) are particularly sensitive to neonatal Caps treatment [3].
  • Overall our results suggest that Caps when administered at birth, profoundly affects T cell differentiation, likely through its ability to activate apoptotic cell death program [3].
  • Typically, a 10-microl sample was mixed with 10 microl derivatization reagent containing 0.45 M Caps buffer (pH 12.0), 0.2 M benzylamine, 10 mM potassium hexacyanoferrate(III), and N,N-dimethylformamide (1:1:1:15, v/v) [4].
 

Biological context of Cadps

  • The lipid peroxidation was found inhibited (50%) by 48.5 microg/ml of Caps HT2 [1].
  • The formulation, Caps HT2 was found to scavenge superoxide and hydroxyl radicals; the IC50 required being 55.0 and 610.0 microg/ml respectively [1].
  • Some zwitterionic buffers had little effect other than that produced by increasing osmolality but Tricine, Popso and Caps produced marked additional inhibition of anion uniport and several other zwitterionic buffers were also inhibitory [5].
 

Associations of Cadps with chemical compounds

 

Analytical, diagnostic and therapeutic context of Cadps

  • In the present study we investigated the effect of Caps administration to neonatal rats on thymocyte subpopulation distribution and functions at different times after treatment [3].
  • Antiatherogenic effect of Caps HT2, a herbal Ayurvedic medicine formulation [1].

References

  1. Antiatherogenic effect of Caps HT2, a herbal Ayurvedic medicine formulation. Mary, N.K., Babu, B.H., Padikkala, J. Phytomedicine (2003) [Pubmed]
  2. Platelets do not modulate leukocyte-mediated coronary microvascular damage during early reperfusion. Reynolds, J.M., McDonagh, P.F. Am. J. Physiol. (1994) [Pubmed]
  3. Impairment of rat thymocyte differentiation and functions by neonatal capsaicin treatment is associated with induction of apoptosis. Santoni, G., Perfumi, M.C., Pompei, P., Spreghini, E., Lucciarini, R., Martarelli, D., Staffolani, M., Piccoli, M. J. Neuroimmunol. (2000) [Pubmed]
  4. Determination of norepinephrine in microdialysis samples by microbore column liquid chromatography with fluorescence detection following derivatization with benzylamine. Yamaguchi, M., Yoshitake, T., Fujino, K., Kawano, K., Kehr, J., Ishida, J. Anal. Biochem. (1999) [Pubmed]
  5. Effect of buffers and osmolality on anion uniport across the mitochondrial inner membrane. Ng, L.T., Selwyn, M.J., Choo, H.L. Biochim. Biophys. Acta (1993) [Pubmed]
 
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