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Gene Review

UL33  -  interacts with DNA packaging terminase...

Human herpesvirus 1

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Disease relevance of UL33

  • The herpes simplex virus UL33 gene product is required for the assembly of full capsids [1].
  • We also investigated an HSV-1 mutant with a defect in gene UL33, the product of which is also thought to be involved in viral DNA processing and packaging [2].

High impact information on UL33

  • In contrast, all of the UL28 insertion mutants were found to interact with UL15 but the interaction was reduced with mutants that failed to react with UL33 [3].
  • It is suggested that conserved proteins UL27-UL33 are encoded near the middle of UL to take advantage of a low local mutation rate [4].
  • The DNA cleavage and packaging protein encoded by the UL33 gene of herpes simplex virus 1 associates with capsids [5].
  • Displacement of ICP35 from replication compartments was not observed in cells infected with cleavage/packaging mutants lacking UL28 and UL33 [6].
  • A mutant with a frameshift mutation in an essential gene (UL33) was isolated by transfecting a complementing cell line [7].

Biological context of UL33

  • Previous results indicated that UL28 interacts with UL15 and UL33 to form a protein complex (terminase) that is presumed to cleave concatemeric DNA into genome lengths [3].
  • Sequence analysis of the DNA in this region from the mutant and two independently isolated revertants for growth revealed that ts1233 had a single base-pair change at the amino-terminal end of UL33, resulting in the substitution of an isoleucine with an asparagine [1].

Other interactions of UL33

  • The ts1233 mutation was mapped by marker rescue to the vicinity of genes UL32 and UL33 [1].


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