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Gene Review

UL20  -  type 3 membrane protein; 4 transmembrane...

Human herpesvirus 1

 
 
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Disease relevance of UL20

 

High impact information on UL20

 

Biological context of UL20

  • Transient-coexpression experiments revealed that the UL20 protein enabled cell surface expression of gK, but not gK-mediated cell-to-cell fusion, indicating that additional viral proteins are required for expression of the gK syncytial phenotype [6].
  • Genetic analysis of the herpes simplex virus type 1 UL20 protein domains involved in cytoplasmic virion envelopment and virus-induced cell fusion [7].
 

Anatomical context of UL20

  • Plasma membrane topology of syncytial domains of herpes simplex virus type 1 glycoprotein K (gK): the UL20 protein enables cell surface localization of gK but not gK-mediated cell-to-cell fusion [6].
  • (iii) In both infected Vero and infected 143TK- cells, the UL20 protein was detected by immunofluorescence in association with nuclear membranes and in the cytoplasm [3].
  • The resultant KOS/UL20-null virus produced small plaques of 8 to 15 cells in Vero cells while it produced wild-type plaques on the complementing cell line G5 [5].
  • Electron microscopic examination of infected cells revealed that the KOS/UL20-null virions predominantly accumulated capsids in the cytoplasm while a small percentage of virions were found as enveloped virions within cytoplasmic vacuoles [5].
  • These results are consistent with the hypothesis that UL20 is a component of virion envelopes and membranes of virion transport vesicles and is selectively retained from the latter in a Golgi compartment [3].
 

Associations of UL20 with chemical compounds

  • (ii) Pulse-chase experiments revealed no detectable alteration in the mobility of the UL20 protein in polyacrylamide gels [3].
  • To delineate the functional domains of the UL20 protein, we generated a panel of single and multiple (cluster) alanine substitutions as well as UL20p carboxyl-terminal truncations [7].
 

Regulatory relationships of UL20

  • Virus infection with the UL11/UL20 double-null virus did not alter the TGN localization of transiently expressed UL11 or UL20 proteins, indicating that these proteins did not interact [8].
 

Other interactions of UL20

  • The putative protein product of the MDV2 UL20 gene had a relatively low homology but that of the MDV2 UL21 gene had a moderate homology among herpesviruses [4].
 

Analytical, diagnostic and therapeutic context of UL20

References

  1. Herpes simplex virus type 1 glycoprotein K and the UL20 protein are interdependent for intracellular trafficking and trans-Golgi network localization. Foster, T.P., Melancon, J.M., Olivier, T.L., Kousoulas, K.G. J. Virol. (2004) [Pubmed]
  2. Herpes simplex virus type 1 gK is required for gB-mediated virus-induced cell fusion, while neither gB and gK nor gB and UL20p function redundantly in virion de-envelopment. Melancon, J.M., Luna, R.E., Foster, T.P., Kousoulas, K.G. J. Virol. (2005) [Pubmed]
  3. Localization and putative function of the UL20 membrane protein in cells infected with herpes simplex virus 1. Ward, P.L., Campadelli-Fiume, G., Avitabile, E., Roizman, B. J. Virol. (1994) [Pubmed]
  4. Identification and DNA sequence analysis of the Marek's disease virus serotype 2 genes homologous to the herpes simplex virus type 1 UL20 and UL21. Hatama, S., Jang, H.K., Izumiya, Y., Cai, J.S., Tsushima, Y., Kato, K., Miyazawa, T., Kai, C., Takahashi, E., Mikami, T. J. Vet. Med. Sci. (1999) [Pubmed]
  5. The herpes simplex virus type 1 UL20 protein modulates membrane fusion events during cytoplasmic virion morphogenesis and virus-induced cell fusion. Foster, T.P., Melancon, J.M., Baines, J.D., Kousoulas, K.G. J. Virol. (2004) [Pubmed]
  6. Plasma membrane topology of syncytial domains of herpes simplex virus type 1 glycoprotein K (gK): the UL20 protein enables cell surface localization of gK but not gK-mediated cell-to-cell fusion. Foster, T.P., Alvarez, X., Kousoulas, K.G. J. Virol. (2003) [Pubmed]
  7. Genetic analysis of the herpes simplex virus type 1 UL20 protein domains involved in cytoplasmic virion envelopment and virus-induced cell fusion. Melancon, J.M., Foster, T.P., Kousoulas, K.G. J. Virol. (2004) [Pubmed]
  8. UL20 protein functions precede and are required for the UL11 functions of herpes simplex virus type 1 cytoplasmic virion envelopment. Fulmer, P.A., Melancon, J.M., Baines, J.D., Kousoulas, K.G. J. Virol. (2007) [Pubmed]
 
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