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Gene Review:

tetR - tetracycline resistance regulatory protein

Salmonella typhimurium

Carattoli, A. et al., Qian, F. et al., Yang, S.J. et al., Allard, J.D. et al.

Carattoli, Filetici, Villa, Dionisi, Ricci, Luzzi,

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Disease relevance of tetR

Typhimurium isolates, particularly ACSSuT type S. Typhimurium, antibiotic resistance genes, cmlA/tetR, bla(PSE-1) and bla(TEM), and genus Salmonella specific gene, sipB/C, were amplified using four pairs of primers in a hot-start multiplex polymerase chain reaction (PCR) [1].

High impact information on tetR

Two DT104 strains, showing resistance to streptomycin-spectinomycin and sulfonamides, carried a partially deleted SGI1 lacking the flo(st), tetR, and tetA genes, conferring chloramphenicol-florfenicol and tetracycline resistance, and the integron harboring the pse-1 gene cassette, conferring ampicillin resistance [2].
To remove the neo gene conferring kanamycin resistance from the locus, a cre expression vector under the control of the tetracycline response promoter was transformed into the clone; expression of the Cre recombinase excised the neo gene and generated the end strain CVD908-tetR [3].
The pIP173 tetR gene is essentially identical to the class D tetR gene from plasmid RA1 [4].

Biological context of tetR

We determined the nucleotide sequence of the pIP173 tetR repressor and tetA resistance genes [4].

References

Antimicrobial resistance in Salmonella enterica serovars Enteritidis and Typhimurium isolated from animals in Korea: comparison of phenotypic and genotypic resistance characterization. Yang, S.J., Park, K.Y., Kim, S.H., No, K.M., Besser, T.E., Yoo, H.S., Kim, S.H., Lee, B.K., Park, Y.H. Vet. Microbiol. (2002) [Pubmed]
Antibiotic resistance genes and Salmonella genomic island 1 in Salmonella enterica serovar Typhimurium isolated in Italy. Carattoli, A., Filetici, E., Villa, L., Dionisi, A.M., Ricci, A., Luzzi, I. Antimicrob. Agents Chemother. (2002) [Pubmed]
Construction of a tetR-integrated Salmonella enterica serovar Typhi CVD908 strain that tightly controls expression of the major merozoite surface protein of Plasmodium falciparum for applications in human Vaccine production. Qian, F., Pan, W. Infect. Immun. (2002) [Pubmed]
Nucleotide sequence of class D tetracycline resistance genes from Salmonella ordonez. Allard, J.D., Gibson, M.L., Vu, L.H., Nguyen, T.T., Bertrand, K.P. Mol. Gen. Genet. (1993) [Pubmed]

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