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Gene Review

Podxl  -  podocalyxin-like

Mus musculus

Synonyms: AW121214, Ly102, PC, PCLP-1, Pclp1, ...
 
 
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Disease relevance of Podxl

 

Psychiatry related information on Podxl

  • All three anti-A. suum-specific HP studied in detail had hapten-binding profiles remarkably similar to each other, a finding that is in contrast to M511 Id+ HP to S. pneumoniae and PC-protein [6].
 

High impact information on Podxl

 

Chemical compound and disease context of Podxl

  • Of the eight anti-P. morganii HP, six exhibited a fine specificity profile for PC and choline analogues only slightly different from M603 Id+ HP induced by S. pneumoniae and PC-protein [6].
  • RESULTS: Among 30 Wilm's tumor (WT)-1- and podocalyxin-positive cell clones, two cell clones stably expressed nephrin as assessed by reverse transcription-polymerase chain reaction (RT-PCR), Northern and Western blotting, and immunofluorescence [8].
 

Biological context of Podxl

 

Anatomical context of Podxl

 

Associations of Podxl with chemical compounds

  • The function of podocalyxin is unknown, but it contains most of the protein bound sialic acid in the glomerulus and is considered vital in the structure and function of the glomerular filtration apparatus [9].
  • We conclude that we have cloned and sequenced a novel transmembrane core glycoprotein from rabbit glomerulus, which has many of the characteristics of podocalyxin [12].
  • Consistent with injury-promoting effects of Galpha qQ > L, there was a significant reduction in podocalyxin mRNA as well as nephrin mRNA and protein levels in glomeruli from TG mice compared with non-TG controls [3].
  • PCP is pyrolyzed at high temperatures to form predominantly 1-phenyl-1-cyclohexene (PC) [13].
  • In addition, PC and its major metabolites, as well as piperidine, are considerably less active behaviorally than PCP, which suggests that pyrolysis represents an inactivation process for PCP [13].
 

Other interactions of Podxl

  • In summary, we find that podocalyxin is a marker of embryonic HSCs and erythroid cells and of adult HSCs and that it may be a valuable marker for the purification of these cells for transplantation [7].
  • RESULTS: As judged by immunostaining for Wilms tumor-1, smooth muscle actin (SMA), podocalyxin, and von Willebrand factor (vWF), we obtained putative endothelial, podocyte and mesangial cell lines [14].
  • The major sialoprotein of the podocyte foot process glycocalyx is a 140-kDa sialoprotein named podocalyxin [12].
  • The phased pattern of newborn mouse ovary differentiation allowed us to (1) extend information on activity and stage specificity of cell type-specific genes; and (2) generate a list of candidate genes involved in primordial follicle formation, including podocalyxin (Podxl), PDGFR-beta, and a follistatin-domain-encoding gene Flst1 [15].
 

Analytical, diagnostic and therapeutic context of Podxl

  • We studied the expression pattern of the major renal protein Podocalyxin during the development of mouse brain using in situ hybridization [11].
  • Sequence alignments and features analysis confirm GP135 as a canine homolog of podocalyxin, confirming the finding of an earlier independent study [16].
  • This study presents (1) a feasibility, direct binding assay, (2) a comparison of methods to immobilize anti-PC upon the fiber (direct immobilization vs an avidin-biotin bridge), and (3) effectiveness of an elution step to regenerate the fiber [17].
  • An immuno-optical biosensor for the diagnosing of PC deficiencies and monitoring of PC concentrations is being developed for this purpose [17].

References

  1. Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin. Doyonnas, R., Kershaw, D.B., Duhme, C., Merkens, H., Chelliah, S., Graf, T., McNagny, K.M. J. Exp. Med. (2001) [Pubmed]
  2. Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia. Kerlin, B.A., Yan, S.B., Isermann, B.H., Brandt, J.T., Sood, R., Basson, B.R., Joyce, D.E., Weiler, H., Dhainaut, J.F. Blood (2003) [Pubmed]
  3. Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury. Wang, L., Fields, T.A., Pazmino, K., Dai, Q., Burchette, J.L., Howell, D.N., Coffman, T.M., Spurney, R.F. J. Am. Soc. Nephrol. (2005) [Pubmed]
  4. Suppression of HIV-1 expression by inhibitors of cyclin-dependent kinases promotes differentiation of infected podocytes. Nelson, P.J., Gelman, I.H., Klotman, P.E. J. Am. Soc. Nephrol. (2001) [Pubmed]
  5. Focal arterial inflammation is augmented in mice with a deficiency of the protein C gene. Castellino, F.J., Ganopolsky, J.G., Noria, F., Sandoval-Cooper, M.J., Ploplis, V.A. Thromb. Haemost. (2006) [Pubmed]
  6. Antigen-specific anti-phosphocholine antibodies: binding site studies. Claflin, J.L., Hudak, S., Maddalena, A., Bender, T. J. Immunol. (1985) [Pubmed]
  7. Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells. Doyonnas, R., Nielsen, J.S., Chelliah, S., Drew, E., Hara, T., Miyajima, A., McNagny, K.M. Blood (2005) [Pubmed]
  8. Stable expression of nephrin and localization to cell-cell contacts in novel murine podocyte cell lines. Schiwek, D., Endlich, N., Holzman, L., Holthöfer, H., Kriz, W., Endlich, K. Kidney Int. (2004) [Pubmed]
  9. Gene structure and alternative splicing of murine podocalyxin: a member of the CD34 sialomucin family. Li, J., Li, Y., Brophy, P.D., Kershawt, D.B. DNA Seq. (2001) [Pubmed]
  10. Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury. Matsusaka, T., Xin, J., Niwa, S., Kobayashi, K., Akatsuka, A., Hashizume, H., Wang, Q.C., Pastan, I., Fogo, A.B., Ichikawa, I. J. Am. Soc. Nephrol. (2005) [Pubmed]
  11. Pattern of expression of the podocalyxin gene in the mouse brain during development. Vitureira, N., McNagny, K., Soriano, E., Burgaya, F. Gene Expr. Patterns (2005) [Pubmed]
  12. Molecular cloning, expression, and characterization of podocalyxin-like protein 1 from rabbit as a transmembrane protein of glomerular podocytes and vascular endothelium. Kershaw, D.B., Thomas, P.E., Wharram, B.L., Goyal, M., Wiggins, J.E., Whiteside, C.I., Wiggins, R.C. J. Biol. Chem. (1995) [Pubmed]
  13. Disposition of phencyclidine and its pyrolytic products in mice exposed to smoke. Martin, B.R., Freeman, A.S. Fed. Proc. (1983) [Pubmed]
  14. Isolation and characterization of conditionally immortalized mouse glomerular endothelial cell lines. Rops, A.L., van der Vlag, J., Jacobs, C.W., Dijkman, H.B., Lensen, J.F., Wijnhoven, T.J., van den Heuvel, L.P., van Kuppevelt, T.H., Berden, J.H. Kidney Int. (2004) [Pubmed]
  15. Mouse ovary developmental RNA and protein markers from gene expression profiling. Herrera, L., Ottolenghi, C., Garcia-Ortiz, J.E., Pellegrini, M., Manini, F., Ko, M.S., Nagaraja, R., Forabosco, A., Schlessinger, D. Dev. Biol. (2005) [Pubmed]
  16. Molecular identification of canine podocalyxin-like protein 1 as a renal tubulogenic regulator. Cheng, H.Y., Lin, Y.Y., Yu, C.Y., Chen, J.Y., Shen, K.F., Lin, W.L., Liao, H.K., Chen, Y.J., Liu, C.H., Pang, V.F., Jou, T.S. J. Am. Soc. Nephrol. (2005) [Pubmed]
  17. Preliminary study of real-time fiber optic based protein C biosensor. Spiker, J.O., Kang, K.A. Biotechnol. Bioeng. (1999) [Pubmed]
 
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