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Chaf1a  -  chromatin assembly factor 1, subunit A (p150)

Mus musculus

Synonyms: AL023013, AL024058, CAF-1, CAF-1 subunit A, CAF-I 150 kDa subunit, ...
 
 
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Disease relevance of Chaf1a

  • To test whether the protective Ags to Yersinia pestis can be orally delivered, the Y. pestis caf1 operon, encoding the F1-Ag and virulence Ag (V-Ag) were cloned into attenuated Salmonella vaccine vectors [1].
  • Hence, a new Salmonella vaccine, Salmonella-(F1+V)Ags, made with a single plasmid containing the caf1 operon and the chimeric promoter for V-Ag allowed the simultaneous expression of F1 capsule and V-Ag [1].
  • In addition, serum from hybrid BALB/cJ x A/J CAF1 mice that had been immunized with the tri-epitope MAP T3-CS-T1 successfully inhibited the malaria sporozoite invasion of hepatoma cells in vitro [2].
  • Spleen cells from normal CAF1 mice responded in mixed leucocyte tumour reactions (MLTR) when cocultured with lymphoma cells [3].
 

High impact information on Chaf1a

  • We propose that perpetuation of heterochromatin involves self-maintenance factors, including local concentration of Hp1alpha and -beta, and that a degree of plasticity is provided by the cycle of H4 acetylation/deacetylation assisted by CAF-1 [4].
  • F1-Ag expression was controlled under a promoter from the caf1 operon; two different promoters (P), PtetA in pV3, PphoP in pV4, as well as a chimera of the two in pV55 were tested [1].
  • Spleen cells from CAF1 mice made tolerant to type III pneumococcal polysaccharide (S3) with S3 coupled to syngeneic spleen cells (S3-SC) develop S3-specific suppressor T cells (Ts) [5].
  • Mammary glands of virgin, pregnant, lactating, and post-weaning CAF1 mice were studied by immunofluorescence for epithelial immunoglobulins and stromal plasma cells [6].
  • We compared the immunogenicity of the engineered monomer with polymeric Caf1 in antigen presentation assays to CD4 T-cell hybridomas in vitro, as well as in the induction of antibody responses and protection against subcutaneous challenge with Y. pestis in vivo [7].
 

Chemical compound and disease context of Chaf1a

  • We report the immunological studies on three transplantable lymphoma lines that developed when CAF1 mice were injected with busulfan and chloramphenicol [3].
  • Protection against virulent plague challenge by the parenteral and aerosol routes was afforded by a single administration of microencapsulated Caf1 and LcrV antigens from Yersinia pestis in BALB/c mice [8].
 

Biological context of Chaf1a

  • The phylogeny of macrophage function: antigen uptake and degradation by peritoneal exudate cells of two amphibian species and CAF1 mice [9].
  • To analyze the role of chromatin assembly factor 1 (CAF-1) during pre-implantation development, we generated a mouse line carrying a targeted mutation in the gene encoding its large subunit, p150CAF-1 [10].
  • Furthermore, loss of CAF-1 in these cells results in the alteration of epigenetic histone methylation marks at the level of pericentric heterochromatin [10].
  • Complete Freund's adjuvant (CFA) administered before sensitization dampened the normal and cyclophosphamide-enhanced response of high and moderate IgE responder phenotype mice (CAF1 and C57B1/6J, respectively) [11].
 

Anatomical context of Chaf1a

  • Specific binding of Caf1 [K(d) = (5.4 +/- 0.1) x 10(-10) M] to interleukin-1 receptors (IL-1Rs) on the surface of finite mouse fibroblasts (line NIH 3T3) was observed [12].
  • Thus, these results help to explain the importance of Caf1 in the interaction of Y. pestis with the host immune system [12].
  • Caf1 is able to inhibit high-affinity binding of (125)I-labeled IL-1beta to NIH 3T3 cells, and in the presence of Caf1, the binding of [(125)I]IL-1beta is characterized by a K(d) of (2.0 +/- 0.3) x 10(-9) M [12].
  • We examined whether this naturally elevated glucocorticoid level is associated with increased apoptotic loss of pre-T cells in the thymus of A/J and CAF1/J mice [13].
 

Associations of Chaf1a with chemical compounds

 

Analytical, diagnostic and therapeutic context of Chaf1a

References

  1. Oral Vaccination with Salmonella Simultaneously Expressing Yersinia pestis F1 and V Antigens Protects against Bubonic and Pneumonic Plague. Yang, X., Hinnebusch, B.J., Trunkle, T., Bosio, C.M., Suo, Z., Tighe, M., Harmsen, A., Becker, T., Crist, K., Walters, N., Avci, R., Pascual, D.W. J. Immunol. (2007) [Pubmed]
  2. Immunogenicity of well-characterized synthetic Plasmodium falciparum multiple antigen peptide conjugates. Joshi, M.B., Gam, A.A., Boykins, R.A., Kumar, S., Sacci, J., Hoffman, S.L., Nakhasi, H.L., Kenney, R.T. Infect. Immun. (2001) [Pubmed]
  3. Busulfan and chloramphenicol induced T cell lymphoma: cell surface characteristics and functional properties. Bhoopalam, N., Price, K., Norgello, H., Barone-Varelas, J., Fried, W. Clin. Exp. Immunol. (1986) [Pubmed]
  4. Duplication and maintenance of heterochromatin domains. Taddei, A., Roche, D., Sibarita, J.B., Turner, B.M., Almouzni, G. J. Cell Biol. (1999) [Pubmed]
  5. Direct demonstration of specific suppressor T cells in the mice tolerant to type III pneumococcal polysaccharide: two-step requirement for development of detectable suppressor cells. Braley-Mullen, H. J. Immunol. (1980) [Pubmed]
  6. Plasma cells and epithelial immunoglobulins in the mouse mammary gland during pregnancy and lactation. Weisz-Carrington, P., Roux, M.E., Lamm, M.E. J. Immunol. (1977) [Pubmed]
  7. Immunogenicity of a Yersinia pestis Vaccine Antigen Monomerized by Circular Permutation. Chalton, D.A., Musson, J.A., Flick-Smith, H., Walker, N., McGregor, A., Lamb, H.K., Williamson, E.D., Miller, J., Robinson, J.H., Lakey, J.H. Infect. Immun. (2006) [Pubmed]
  8. Protection against bubonic and pneumonic plague with a single dose microencapsulated sub-unit vaccine. Elvin, S.J., Eyles, J.E., Howard, K.A., Ravichandran, E., Somavarappu, S., Alpar, H.O., Williamson, E.D. Vaccine (2006) [Pubmed]
  9. The phylogeny of macrophage function: antigen uptake and degradation by peritoneal exudate cells of two amphibian species and CAF1 mice. Gammie, A.E., Ruben, L.N. Cell. Immunol. (1986) [Pubmed]
  10. CAF-1 Is Essential for Heterochromatin Organization in Pluripotent Embryonic Cells. Houlard, M., Berlivet, S., Probst, A.V., Quivy, J.P., H??ry, P., Almouzni, G., G??rard, M. PLoS Genet. (2006) [Pubmed]
  11. Regulation of in vivo IgE biosynthesis in mice with complete Freund's adjuvant. Smith, W.G., Butchko, G.M. Int. Arch. Allergy Appl. Immunol. (1986) [Pubmed]
  12. Structural and functional similarity between Yersinia pestis capsular protein Caf1 and human interleukin-1 beta. Abramov, V.M., Vasiliev, A.M., Vasilenko, R.N., Kulikova, N.L., Kosarev, I.V., Khlebnikov, V.S., Ishchenko, A.T., MacIntyre, S., Gillespie, J.R., Khurana, R., Korpela, T., Fink, A.L., Uversky, V.N. Biochemistry (2001) [Pubmed]
  13. Apoptosis plays a distinct role in the loss of precursor lymphocytes during zinc deficiency in mice. King, L.E., Osati-Ashtiani, F., Fraker, P.J. J. Nutr. (2002) [Pubmed]
  14. Busulfan-induced suppression of natural killer cell activity. Bhoopalam, N., Price, K.S., Norgello, H., Fried, W. Exp. Hematol. (1985) [Pubmed]
 
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