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BHLHE22  -  basic helix-loop-helix family, member e22

Homo sapiens

Synonyms: BHLHB5, Beta3, CAGL85, Class B basic helix-loop-helix protein 5, Class E basic helix-loop-helix protein 22, ...
 
 
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Disease relevance of BHLHB5

 

High impact information on BHLHB5

 

Analytical, diagnostic and therapeutic context of BHLHB5

  • Northern blot analysis of human BHLHB5 revealed brain-specific expression with the highest abundance in the cerebellum [1].
  • Genomic sequence analysis of human BHLHB5 and mouse Bhlhb5 revealed that they contain a single exon encoding 381- and 355-amino-acid bHLH proteins, respectively [1].

References

  1. Functional and structural characterization of the human gene BHLHB5, encoding a basic helix-loop-helix transcription factor. Xu, Z.P., Dutra, A., Stellrecht, C.M., Wu, C., Piatigorsky, J., Saunders, G.F. Genomics (2002) [Pubmed]
  2. Beta3 receptors mediate relaxation in stomach fundus whereas a fourth beta receptor mediates tachycardia in atria from transgenic beta3 receptor knockout mice. Cohen, M.L., Bloomquist, W., Ito, M., Lowell, B.B. Recept. Channels (2000) [Pubmed]
  3. Pathogenic hantaviruses selectively inhibit beta3 integrin directed endothelial cell migration. Gavrilovskaya, I.N., Peresleni, T., Geimonen, E., Mackow, E.R. Arch. Virol. (2002) [Pubmed]
  4. Beta 3 integrin-mediated fibrin clot retraction by nucleated cells: differing behavior of alpha IIb beta 3 and alpha v beta 3. Chen, Y.P., O'Toole, T.E., Leong, L., Liu, B.Q., Diaz-Gonzalez, F., Ginsberg, M.H. Blood (1995) [Pubmed]
  5. Beta3 tyrosine phosphorylation in alphaIIbbeta3 (platelet membrane GP IIb-IIIa) outside-in integrin signaling. Phillips, D.R., Nannizzi-Alaimo, L., Prasad, K.S. Thromb. Haemost. (2001) [Pubmed]
  6. Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells. Galliher, A.J., Schiemann, W.P. Breast Cancer Res. (2006) [Pubmed]
  7. Association of beta-adrenoceptor single nucleotide polymorphisms with resting heart rate. Xie, Z., Niuk, Y., Ma, H., Yin, Y., Liu, Z., Li, Z. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference (2004) [Pubmed]
 
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