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Pdhx  -  pyruvate dehydrogenase complex, component X

Mus musculus

Synonyms: AI481367, Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex, E3bp, Lipoyl-containing pyruvate dehydrogenase complex component X, Pdx1, ...
 
 
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Disease relevance of Pdhx

  • Tissue microarrays containing gastric cancers from the fundus and antrum and samples of SPEM and intestinal metaplasia were immunostained for Pdx-1 [1].
  • We have therefore sought to examine the presence of Pdx-1 expression in gastric metaplasias and gastric adenocarcinoma in humans [1].
 

High impact information on Pdhx

  • Although SPEM lineages did not show any staining for Pdx-1, intestinal metaplasia showed strong nuclear staining for Pdx-1 [1].
  • The transcription factor Pdx-1 is expressed in the adult pancreatic islet cells as well as the gastric antrum and duodenum [1].
  • Given the pattern of normal Pdx-1 expression in the duodenum, goblet cell metaplasia in the stomach may reflect the adoption of a duodenal lineage paradigm [1].
  • Although it is possible to obtain replicating cells from cultures of adult pancreas, these cells, when significantly expanded in vitro, progressively lose pancreatic-specific gene expression, including that of a "master" homeobox transcription factor Pdx1 [2].

References

  1. Expression of Pdx-1 in human gastric metaplasia and gastric adenocarcinoma. Leys, C.M., Nomura, S., Rudzinski, E., Kaminishi, M., Montgomery, E., Washington, M.K., Goldenring, J.R. Hum. Pathol. (2006) [Pubmed]
  2. The defined combination of growth factors controls generation of long-term-replicating islet progenitor-like cells from cultures of adult mouse pancreas. Ta, M., Choi, Y., Atouf, F., Park, C.H., Lumelsky, N. Stem Cells (2006) [Pubmed]
 
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